WEBVTT
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I'm going to introduce all the
speakers before each center gets
their talk.

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I also want to let you know, in
advance these are short bios,
they

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are full bios each presenter
available on the webinar page of
the

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presenters tab. Feel free to
take a look at that, if

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you'd like to learn more about
each speaker. So, we will get
started

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with the University of Kentucky
SRP center, first, we will hear

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from Dr. Kerry Pennell Senator
lector director contaminants,
agent

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piping systems project, as well
as the data management and
analysis

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core. Dr.

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Pennell research notebook and
field studies transport of
halogenated

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organic compounds expense
conducting site characterization
activities,

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Superfund sites, developing

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computational tools to
investigate environmental

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transport processes, also hear
from Dr.

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Pan Deng Assistant Professor
Department of pharmaceutical

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sciences, coinvestigator of the
Kentucky SRP project, Superfund

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chemicals nutrition multiorgan
cardiovascular risk led by
Bernie Henning,

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synthesis of lipids homeostasis,
induced by chemical pollutants,

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underlying cardiovascular
disease risk. Finally, we will
hear

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from Dr. Angela Gutierrez
postdoctoral scholar mentorship

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of Dr. J Zach tilts, UK SRP
center liaison,

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various activities, of the
ministration court, management
analysis

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core, research experience
training coordination core. Also
involved

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in diversity initiatives with
the center your survey

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of Kentucky office vice
president for research award of
the NHS award

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that, I will turn it over to Dr.
Pennell who will begin the

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presentation. Thank you Sara,
so, I am Kelly

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Pennell my pleasure to tell you
the University of Kentucky
Superfund

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research center.

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We are motivated, by health
disparities, located throughout
the central appellation

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region, central appellation
region, area here,

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outlined in red, Kentucky, is
located here, really in the
heart of the

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center appellation region
Eastern Kentucky, located right
in here.

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In this region, we experience a
higher risk of premature

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death, due to diabetes,
cardiovascular disease, adult
obesity, as compared

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to the national average. In fact
we also experience, more
physically

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unhealthy days per month, in
addition,

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also have, our share of
Superfund sites, environmental
contamination.

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Currently 13 active national
priorities, cyclists

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national priority list sites, in
Kentucky.

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We have, PCBs, chlorinated
prevalent throughout Kentucky,

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now, rest of the United states,
many parts of the world, we are

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faced with a better
understanding fluorinated

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substances, or PFA S, UK
Superfund research center to

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investigate or understand, these
pollutant types.

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In addition to the federal,
Superfund sites, we also have,

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250-Kentucky that are considered
state led

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Superfund sites state agencies
lead investigations.

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These are sites where there are
not, well known responsible
parties,

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these are left as, just a
burden, for our state to clean
up. There

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are more than 400 sites still
pending review.

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We are burdened with health
disparities, and environmental
pollution.

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In addition, regionally also
have our share of toxic so that
I hope

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Ohio River, northern boundary of
Kentucky, of course a very
important

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regional waterway, is known to
have, PCB contamination, also,
notorious

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part of the tragic

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story that is enfolded across
United States, Kentucky
Southeast border,

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we have some the highest health
disparities, so again, not

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only in Kentucky but regionally,
this is a problem for toxics and

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health disparities this
motivates our research center,

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has for many many years.

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So, are Superfund research
center uses the prevention
intervention

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paradigm, are projects that are
part of the medical research,
which

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are here in purple, part of
disease prevention, and that are

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projects here, shown in green,

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which are part of our
environmental engineering

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and science, work on exposure
reduction, together, we worked
to improve public

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health. Not just in Kentucky,
but our research generalizable
it works

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to improve public health in many
different layers.

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Our center has a combined
integrated focus working with
many different

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core of the projects, we can
work synergistically to achieve

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our goals, and outcomes. Were
going to start, with, Dr.

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Pan Deng to talk about her
projects begin talking about
Roger?

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One and two, biomedical research
projects. With his I will headed

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over to her.

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>> Thanks, Kelly, and Sara, this
is it is my great

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pleasure to talk about,
biomedical projects, and hours
Superfund research

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center, organic pollutants,
PCBs, and

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PFAS metabolic function, and
cardio

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metabolic disease such as, many
reasons estimate linked

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to the pathology of PCP, induced
cardio metabolic disease with
multiorgan

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system including, guts and the
liver.

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Previous data, demonstrates
that, metabolized plays an

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important role in this process,
bioactive lipid, project

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one aims, understanding how,
multiorgan contributes to
pollutants

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induced cardio metabolic
disease, how to modulate risk

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nutritional intervention, with
that in mind, we use this, space

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approach, and combine that, with

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animal models, to explore,
toxicity in the environmental

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disease risk nutritional
intervention.

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Animals elaborate as humans

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phenotype, also, help us to
discover biomarkers in the

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environmental those can also be
used, as targets nutritional to

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reduce, the risk this works with
supported by

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core, here I want to highlight,
our nutritional intervention

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here, shows us, structure of
dietary

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fiber, promotes gastrointestinal
health, helps lower, blood

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lipid level, reduce the risk of
developing cardiovascular
disease,

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in the study treated the mice
with supplemented diet,

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it can protect against PCD
induced microbial dysfunction,

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liver vascular information
inflammation, for all the fibers

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that we eat, actually cannot be
absorbed directly.

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Microbial metabolized fibers,
generate metabolized --

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Those, metabolized act as
molecule, play important

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role in the microbial
medication.

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So to move this project forward,
in order to

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understand, how dietary fiber is
metabolized, micro biomes,

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modulate reduce risk and develop
this platform,

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based stable results, incubated

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carbon folate label with the

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microbial cell.

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Into the comprehensive,
metabolic pathway. This
generates,

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very unique metabolite specific
to the microbial cells.

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New insights into how, fiber can
modulate microbial metabolism,

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this knowledge, intervention.
So, our project

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aims at understanding, how to

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pollutant, like PCB 126.
nursing, impacts

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diabetes, health outcomes. Also
want to know,

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whether maternal lifestyle
intervention, you nutrition
excise prenatal

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provides beneficial effects, to
reduce risk

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additionally, have investigated,
live genetic

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for example, to the protection
against PCB exposure, here I
want

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to highlight, our maternal
excise study, divided them, into

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four different experiments of
groups,

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mama mice, X ice crew, military
excise, before, during

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and, during mating, pregnancy,
mother mice,

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PCB 126. during the prenatal
period,

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body weight of the baby mice,
were recorded, body composition,

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glucose tolerance, measured up
to 6 months of age, we felt
that,

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in euro, nursing PCD exposure
caused

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significant elevation in body
weight, disposition

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of male adults, offspring.

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Also, the prenatal PCD exposure,

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is a significant delay, in
glucose compared to those

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exposed animals, what is really
fascinating,

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as, maternal during pregnancy,
increase, also,

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and proved glucose exposure in a
PCD exposed offspring.

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So, to summarize what we have
found, in project two,

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male offspring more sensitive to
prenatal PCD

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one exposure, compared to the
unusual exposure,

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may impact the long-term
programming of, diabetes.
Intervention

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tested, maternal excise,
behavior

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protection against toxicity
associated with PCD exposure,

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I will stop here, Dr. will talk
more about our project

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three, and four, thank you.

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>> Thank you, switching gears
little bit focusing

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on research conducts undated
environmental engineering

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science project. Project 3.
worked on developing responsive

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materials for sensing organics.
The goal project

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invest get the use of advanced
membrane, materials,

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composite based sustainable
technologies to

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prevent and reduce environmental
exposure risk, associated with
such

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as PCB, and PFAS. One such
technology

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works on, reduce graphing
off-site membrane, toxic

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organics, here we have,
integrated advanced provided by

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magnetic particles, with, the
membrane. In doing so catalyst

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has been, immobilized within the
membrane,

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and, localized degradation.

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Works with, larger organic
contaminants also

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helps extend the live of the
membrane, this technology allows
easy control

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the extent of reaction.

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Reasonably doctors team

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responsive membrane, temperature
absorption, here

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the microbial have been
converted to a high temperature

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responded platform using in
order to obtain a temperature

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response triggers absorption, of
these contaminants, this is
provided

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by the Hydro for Lincoln

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solution temperature, water
insoluble, in

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this case interest, the graph,
temperature

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membranes, pressure 3.5
absorption, from water,

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desorption from cycles.

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Temperature, responsive membrane
over carbon absorption high
temperatures

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need to generate the carbon,
generation process.

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Within project three, we have
opportunity,

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some of our research into
patents, other technologies.
Example

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of this, developing of smart
PFAS contaminated water.
Material development

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with project properties,
allowing for submission

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professional patent, phase one
grant recently was funded. Very
exciting

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for me since I, principal
investigator in this grant,
continue working

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Superfund, dividing percent of
my time advanced materials to
work

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on this project.

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Project four deals with the
transfer of

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contaminants aging piping
system, exposure risk drinking
water

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associate with substances,
combining

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environmental state and transfer
times can computational model,

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approaches to develop solutions,
ways accessible to communities.

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Sewer and drinking water
systems, out of date. In
addition

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they are expensive, U.S.
American society civil engineers
reports,

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poor rest water drinking water
is a D-, over 1 million sewer

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lines over 1 million drinking
water lines. In the U.S., these
lines

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are neither streets, too often,

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aging and for structure, not

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been considered, groundwater
plumes

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long distances, impacting many
individuals mitigating drinking
water exposure

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risk on better focus groundwater
contamination is known, however

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potential exposure risks don't
think about plumes,

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hypothetical, here's a five mile
plume, public roads have

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been noted, over here. And here.

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Currently regulations, keep the
plume away from them,

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from the road however, what
about the drinking water, sewer
line,

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lie underneath the plume promote
entry into indoor spaces.

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Here, Dr.

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and proceeded sewer system,
contaminated

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groundwater infiltrating into
it, sewer system shown on the
blue area,

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expanded exposure risk, into the
community.

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Far beyond originally designated
groundwater plume, noted in
paint.

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Group, collaborated with several
different

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sample including EPA region
nine, field study over several
year period

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of us the results, show how
temporally and spatially well
defined

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area groundwater plumes.

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As part of project four, learn
how aging sewer systems can

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impact exposure, recently
developed a new computational
model estimate

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TCE. This model can incorporate,
the effects of specifics of
building

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construction. Use field data
from home but is been

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extensively set department of
defense, for space site.

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Photoshop, upper corner.

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This, connected to a piping
system, as you can see,

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down here. And though land
system was connected to the

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foundation, into the indoor
space of the home, 14 user new
models

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predict in the home all over all
four seasons, models very

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good agreement national data,
the first model to be used to
investigate

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TCE entered the homes, approach
was

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the model, approach, modeling
approach open access available
for anyone

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that might be interested.

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Project 14 also been working on
model,

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substances exposure, tricky
water systems in Kentucky.
Developed relationships,

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stakeholders, community groups
to contextualize their
knowledge. This

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figure shows, conceptual models
PFAS develop, have generated

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spatial models, identify areas
in Kentucky, that may be more or

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less, prone to PFAS and drinking
water.

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This figure shows, the results
for a heat map Kentucky, past
injectable

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00:19:03.000 --> 00:19:07.000
industrial processes may suggest
PFAS

296
00:19:07.000 --> 00:19:11.000
contamination is likely, project
for also has several other
layers

297
00:19:11.000 --> 00:19:14.000
heat maps, a valuate sewer
lines, drinking water,
communities

298
00:19:14.000 --> 00:19:18.000
are being served by them. So
from this map,

299
00:19:18.000 --> 00:19:22.000
statistical model, project were
developed to protect the
likelihood

300
00:19:22.000 --> 00:19:24.000
of PFAS being detected,
developed this model

301
00:19:24.000 --> 00:19:30.000
drinking water simply conducted
2019. 80% accurate, for

302
00:19:30.000 --> 00:19:33.000
the 2019 results.

303
00:19:33.000 --> 00:19:39.067
Project four, potentially
interesting spatial

304
00:19:39.067 --> 00:19:43.067
reps, refining models following
the sampling results in
addition,

305
00:19:43.067 --> 00:19:47.000
continuous TCE modeling, field
studies related to TCE, over

306
00:19:47.000 --> 00:19:51.000
the past several weeks
collaborating with EPA, part of
field

307
00:19:51.000 --> 00:19:57.000
study, community setting. Data
will be helpful transfer model.

308
00:19:57.000 --> 00:20:00.000
With Atlanta vector Dr.

309
00:20:00.000 --> 00:20:06.000
Pennell talk about some of the
reports.

310
00:20:06.000 --> 00:20:08.000
>> Thank you Angela.

311
00:20:08.000 --> 00:20:12.000
So, we have several cores that
help support and integrate the
research

312
00:20:12.000 --> 00:20:17.000
that we conduct, within our
Superfund research center. One

313
00:20:17.000 --> 00:20:21.000
of the most critical course,
that helps to get our research,
out into

314
00:20:21.000 --> 00:20:27.000
the community, is a community
engagement core. This core, led
by Dr. Don

315
00:20:27.000 --> 00:20:33.000
Brewer, Dr. at the program
manager, Andy this core,

316
00:20:33.000 --> 00:20:36.000
helps contextualize the
research, being conducted,
especially

317
00:20:36.000 --> 00:20:40.067
within our biomedical research
project, project one and two,

318
00:20:40.067 --> 00:20:46.000
develops partnerships,
communities, who are affected
by,

319
00:20:46.000 --> 00:20:51.000
hazardous waste, also help
disparities, as I spoke about at
the very beginning

320
00:20:51.000 --> 00:20:56.000
of our presentation. Develops
solutions, really appropriate,

321
00:20:56.000 --> 00:21:00.000
accepted by communities, to
address poor diet,

322
00:21:00.000 --> 00:21:04.000
increasing physical activity,
and then, high rates of obesity
and

323
00:21:04.000 --> 00:21:06.000
chronic diseases.

324
00:21:06.000 --> 00:21:11.000
The overall goal of our
community engagement core, to
improve diet,

325
00:21:11.000 --> 00:21:16.000
by increasing, fruit and
vegetable consumption,

326
00:21:16.000 --> 00:21:19.000
increased physical activity,
provide education and awareness
of our,

327
00:21:19.000 --> 00:21:21.000
environmental pollution. Really
important part of the committee

328
00:21:21.000 --> 00:21:24.000
engagement core assessment
evaluation.

329
00:21:24.000 --> 00:21:30.000
Every activity, and program they
conduct, always

330
00:21:30.000 --> 00:21:35.000
evaluated, and assessed. As one
example, of a program

331
00:21:35.000 --> 00:21:39.067
or committee engagement core has
conducted,

332
00:21:39.067 --> 00:21:42.067
care program, state fruit of
Kentucky, is the blackberry, so,
this Barry

333
00:21:42.067 --> 00:21:48.000
actually grows very well in
Kentucky, well loved by

334
00:21:48.000 --> 00:21:52.000
many Kentuckians. Committee
engagement core developed a very
care program,

335
00:21:52.000 --> 00:21:57.000
originated in 2016. now connects
research that was

336
00:21:57.000 --> 00:22:01.000
originated within, project one,
and showed some nutrients can be

337
00:22:01.000 --> 00:22:08.000
protective against,
environmental so when they going
to communities,

338
00:22:08.000 --> 00:22:12.000
talk about research, specifics,
some of the animal model
research,

339
00:22:12.000 --> 00:22:16.000
but then, more in Portland and
talk about fruit and vegetable
intake.

340
00:22:16.000 --> 00:22:20.000
Especially, how blackberries can
be part of a healthful diet,

341
00:22:20.000 --> 00:22:26.000
and they plant, blackberry
bushes, which are easy to
sustain, increase

342
00:22:26.000 --> 00:22:29.000
physical activity, really
support and overall well-being.

343
00:22:29.000 --> 00:22:33.000
They work with senior citizen
groups, and, several senior
citizen centers,

344
00:22:33.000 --> 00:22:38.000
these, blackberry bushes, have
been planted, now being
maintained.

345
00:22:38.000 --> 00:22:43.067
The Barry care program, now in
seven counties,

346
00:22:43.067 --> 00:22:48.000
five of which are in the
appellation region, you can see,
purple area

347
00:22:48.000 --> 00:22:52.000
over here, this is, over Eastern
Kentucky,

348
00:22:52.000 --> 00:22:57.000
that we also have them into
areas here in central Kentucky.
In 2020.

349
00:22:57.000 --> 00:23:00.000
which of course was a difficult
year, has been a difficult year

350
00:23:00.000 --> 00:23:05.000
for doing a lot of committee
engagement due to covert Barry
care still able

351
00:23:05.000 --> 00:23:09.000
to expand one of the senior
center 70 bushes planted,

352
00:23:09.000 --> 00:23:15.000
two centers that serve 50 older
adults.

353
00:23:15.000 --> 00:23:19.000
Barry care also expanded to home
gardeners interested mess, 90
families,

354
00:23:19.000 --> 00:23:24.000
across five eastern counties,
five blackberry bushes, plant
them

355
00:23:24.000 --> 00:23:25.000
at home.

356
00:23:25.000 --> 00:23:30.000
One thing maybe some people
don't realize, and rural areas,

357
00:23:30.000 --> 00:23:34.000
especially Eastern Kentucky to
have the problem of food deserts

358
00:23:34.000 --> 00:23:38.000
only a lack of, fruits and
vegetables, blackberry bushes
are

359
00:23:38.000 --> 00:23:43.067
really a welcome addition, to
the diet, of many

360
00:23:43.067 --> 00:23:46.000
for Kentucky families.

361
00:23:46.000 --> 00:23:49.000
Data management analysis core,
new to University of Kentucky,

362
00:23:49.000 --> 00:23:54.000
Superfund research center, this
is really become a help, to our

363
00:23:54.000 --> 00:24:01.000
entire center. We manage allied
analyze chemistry

364
00:24:01.000 --> 00:24:06.000
and bio modeling to enter
modeling outputs, important to

365
00:24:06.000 --> 00:24:12.000
the project one data, Dr. down
talked about, with analysis,

366
00:24:12.000 --> 00:24:16.000
more portly, critical as we
conduct interviews with each

367
00:24:16.000 --> 00:24:20.000
of our projects over extreme
mental plans, a lot of
integrate, but are

368
00:24:20.000 --> 00:24:25.000
understand, however research
supports, and,

369
00:24:25.000 --> 00:24:31.000
can relate to each other,
throughout our center. We also,
able to share

370
00:24:31.000 --> 00:24:35.000
data, and understand how each of
us and interact with each

371
00:24:35.000 --> 00:24:40.000
other, more meaningful ways. So,
this GMAC

372
00:24:40.000 --> 00:24:43.000
really become the hub, and, Dr.

373
00:24:43.000 --> 00:24:47.934
Angela Gutierrez created a new
position

374
00:24:47.934 --> 00:24:51.934
for the SRP liaison, one of our
very important spokes that

375
00:24:51.934 --> 00:24:57.934
helps us, to connect from the
DMAC all the other parts, part
of our

376
00:24:57.934 --> 00:25:01.934
admin core, DMAC and our,
research experience coordination

377
00:25:01.934 --> 00:25:03.934
core for the trainee.

378
00:25:03.934 --> 00:25:07.934
It is been a very critical part,
to make sure all those different

379
00:25:07.934 --> 00:25:10.934
pieces are connecting.

380
00:25:10.934 --> 00:25:19.934
You biomonitoring environmental
we refer to as

381
00:25:19.934 --> 00:25:25.934
BEACC analyzing simple stem from
this

382
00:25:25.934 --> 00:25:29.934
project all of us need samples,
analyzed whether there from
animal

383
00:25:29.934 --> 00:25:34.934
models, or, bio specimens or
samples from water, or,

384
00:25:34.934 --> 00:25:38.934
skill set of the nearby mental
engineering and science
projects.

385
00:25:38.934 --> 00:25:44.000
But BEACC is very critical
directly connects to the

386
00:25:44.000 --> 00:25:51.000
trench when this continues to be
a very critical part of our UK
SRC.

387
00:25:51.000 --> 00:25:57.000
Going to switch gears for now,
headed back to Dr.

388
00:25:57.000 --> 00:25:59.000
Gutierrez critical part of our
research expense

389
00:25:59.000 --> 00:26:02.000
training coordination core,
before you, just want to point
out, it

390
00:26:02.000 --> 00:26:05.000
was no accident, that we had Dr.

391
00:26:05.000 --> 00:26:08.000
Pan Deng and Dr. Gutierrez be
part of

392
00:26:08.000 --> 00:26:13.000
our presentation today. Dr. Pan
Deng begins a

393
00:26:13.000 --> 00:26:18.000
postdoc within UK SRC received
training, and UK SRC Dr.
Gutierrez,

394
00:26:18.000 --> 00:26:22.000
was a winner, as a part of SRC,

395
00:26:22.000 --> 00:26:28.000
even rich expenses really really
important, within

396
00:26:28.000 --> 00:26:32.000
UK SRC we believe in, exactly
what, VRS four

397
00:26:32.000 --> 00:26:37.000
is doing very important to all
of us, within UK SRC. So

398
00:26:37.000 --> 00:26:39.067
the fact that Angela is now part
of the leadership team here, is

399
00:26:39.067 --> 00:26:44.067
again, no accident it was deftly
part of planning.

400
00:26:44.067 --> 00:26:49.000
With great pride, like to have
this last part of a
presentation,

401
00:26:49.000 --> 00:26:52.000
back to Dr. Angela Gutierrez

402
00:26:52.000 --> 00:26:58.000
>> Thank you, those are very
kind words I am

403
00:26:58.000 --> 00:27:02.000
incredibly excited to have grown
throughout the UK SRC, done from

404
00:27:02.000 --> 00:27:07.000
a trainee, being able to work
participate as part of other
course,

405
00:27:07.000 --> 00:27:11.000
experience training coordination
core,

406
00:27:11.000 --> 00:27:19.000
VRS four investigate issues,
exposing them to training,

407
00:27:19.000 --> 00:27:20.334
enhance professional career

408
00:27:20.334 --> 00:27:23.000
development, and, through
extensive outside experiences

409
00:27:23.000 --> 00:27:29.000
program, coordinator
opportunities organization
engagement core administered

410
00:27:29.000 --> 00:27:32.000
of course research function,
engaging them with the data
management

411
00:27:32.000 --> 00:27:38.000
analysis core. These diverse
activities environmental issues,
affect the

412
00:27:38.000 --> 00:27:44.067
surroundings equips them from
unique toolsets, impact in the
field.

413
00:27:44.067 --> 00:27:49.000
Recently, UK SRC organizer
training developed

414
00:27:49.000 --> 00:27:53.000
public grant program, aim to
foster cross disciplinary
projects,

415
00:27:53.000 --> 00:27:59.000
two or more projects, cores help
strengthen interactions,

416
00:27:59.000 --> 00:28:03.000
collaborations within the UK SRC
this program, enable new
research

417
00:28:03.000 --> 00:28:09.000
directions, exploration of
collaborative context,

418
00:28:09.000 --> 00:28:12.000
valuable expense, finding and
securing collaborative research
projects

419
00:28:12.000 --> 00:28:17.000
primary focus. As well is,
experiencing grant writing and

420
00:28:17.000 --> 00:28:23.000
project management. The first
Pelz grant, has been funded

421
00:28:23.000 --> 00:28:27.000
rumination of Kentucky PFAS
hotspots,

422
00:28:27.000 --> 00:28:33.000
project three project for
trainees came up as a training
led

423
00:28:33.000 --> 00:28:38.000
came out, one of our, training
led meetings, mutual insurance,
collaborate,

424
00:28:38.000 --> 00:28:42.067
more research and expense for
them, the

425
00:28:42.067 --> 00:28:46.000
aim of this project to analyze,
remediate real-world water
samples

426
00:28:46.000 --> 00:28:49.000
potentially highly contaminated
drinking and wastewater systems

427
00:28:49.000 --> 00:28:54.000
throughout Kentucky, here
combining research from project
four,

428
00:28:54.000 --> 00:28:58.000
identifies potential PFAS
hotspots throughout Kentucky

429
00:28:58.000 --> 00:29:03.000
statistical analysis, research
from project three PFAS

430
00:29:03.000 --> 00:29:09.000
development. As part of the
research, training, coordination

431
00:29:09.000 --> 00:29:14.000
core, also organized data
management, and a shift or
provide

432
00:29:14.000 --> 00:29:19.000
tools for the trainees, graduate
program, future careers,

433
00:29:19.000 --> 00:29:25.000
upcoming workshop, new
programming languages,
statistical analysis

434
00:29:25.000 --> 00:29:31.000
pandemic forcing forcing some of
our online, very

435
00:29:31.000 --> 00:29:35.000
useful tool. Created a training
group, connected, motivating

436
00:29:35.000 --> 00:29:38.000
each other through these
difficult times,

437
00:29:38.000 --> 00:29:44.067
conducted our monthly training
led meeting, so the platform

438
00:29:44.067 --> 00:29:51.000
seminars, conferences both UK
has, the other Superfund
centers, provide.

439
00:29:51.000 --> 00:29:55.000
And, with this, I would like to
end her presentation opened up
for

440
00:29:55.000 --> 00:30:00.000
any questions you might have.
Thank you.

441
00:30:00.000 --> 00:30:03.000
>> Thank you so much, Dr.

442
00:30:03.000 --> 00:30:08.000
Gutierrez, we will now get this
questions,

443
00:30:08.000 --> 00:30:11.000
just a reminder, you may cement
your questions, using the Q&A
part,

444
00:30:11.000 --> 00:30:17.000
see in the lower right-hand
corner, the first question I see
come in,

445
00:30:17.000 --> 00:30:22.000
very clear sense of the great
project, our participant
selected

446
00:30:22.000 --> 00:30:27.000
for it, what kind of outputs,
very care being measured, and
how?

447
00:30:27.000 --> 00:30:33.000
>> So, unfortunately we don't

448
00:30:33.000 --> 00:30:36.000
have Dr. Don Brewer on here who
actually leave that. But,

449
00:30:36.000 --> 00:30:42.067
the way that participants are
typically selected, are, with

450
00:30:42.067 --> 00:30:46.000
existing partnerships, our
communities, and then, we within
the University

451
00:30:46.000 --> 00:30:50.000
of Kentucky, we have, land-grant
we have

452
00:30:50.000 --> 00:30:55.000
extension agents, hundred and 20
counties, so it started with,
our

453
00:30:55.000 --> 00:31:01.000
existing partnerships, now, very
care is,

454
00:31:01.000 --> 00:31:05.000
expending through all of this
120 counties, each county has an
extension

455
00:31:05.000 --> 00:31:11.000
agent, so, it can grow in that
way as well. There's an interest

456
00:31:11.000 --> 00:31:13.000
it can, expand.

457
00:31:13.000 --> 00:31:19.000
So that is going to be how it
continues to expand, it has,

458
00:31:19.000 --> 00:31:23.000
it will develop, I believe it
already has written up
curriculum

459
00:31:23.000 --> 00:31:26.000
with this, I know it has some
curriculum, as it gets into the
extension program

460
00:31:26.000 --> 00:31:30.000
actually specific criteria for
it to be, published in the
extension

461
00:31:30.000 --> 00:31:33.000
curriculum I'm not sure if it's
fully published in that. It
includes,

462
00:31:33.000 --> 00:31:38.000
things on environmental
pollution as well as,

463
00:31:38.000 --> 00:31:42.067
vital nutrient benefits of
blackberries, recipe cards, one
thing I just want

464
00:31:42.067 --> 00:31:45.067
to point out, that every, well,
I personally enjoy

465
00:31:45.067 --> 00:31:49.000
blackberry jam, blackberry pie
that is not something that, are
community

466
00:31:49.000 --> 00:31:55.000
engagement core is necessarily
promotes, they promote things
that are helpful,

467
00:31:55.000 --> 00:32:02.000
with good dietary benefits, so,
their recipe cards,

468
00:32:02.000 --> 00:32:05.000
with the final nutrient
benefits, of those, so that
would be part

469
00:32:05.000 --> 00:32:08.000
of the curriculum they put
forward, in addition to how to
plant and

470
00:32:08.000 --> 00:32:12.000
care for them it has to be put
in with the community that would
be

471
00:32:12.000 --> 00:32:14.000
willing to maintain his
blackberry plants, which are
fairly well easy

472
00:32:14.000 --> 00:32:20.000
to maintain. The other thing,
they measure are things like
scraps from

473
00:32:20.000 --> 00:32:25.000
the blackberries, once they make
a blackberry dish, how many
scraps

474
00:32:25.000 --> 00:32:30.000
to the actually way, food
contents, food scraps, and

475
00:32:30.000 --> 00:32:35.000
then, they also do some
awareness testing,

476
00:32:35.000 --> 00:32:40.067
with qualitative testing, so,
how much did awareness of,

477
00:32:40.067 --> 00:32:44.067
nutrition increase, how much
did, dietary intake you know,

478
00:32:44.067 --> 00:32:49.000
change and how much
environmental pollution change,
those

479
00:32:49.000 --> 00:32:53.000
of the types of things that
they, evaluate.

480
00:32:53.000 --> 00:32:57.000
>> If I may add, great
interaction with the trainees,
we've had several,

481
00:32:57.000 --> 00:33:02.000
trainees, and present their
research especially, nutritional

482
00:33:02.000 --> 00:33:04.000
aspects of the biomedical
research.

483
00:33:04.000 --> 00:33:10.000
And, usually, when it comes to
the senior citizens, they, do

484
00:33:10.000 --> 00:33:13.000
love having interaction with
younger people, has also
provided a way

485
00:33:13.000 --> 00:33:18.000
for our trainees to be able to
sit disseminate their research
in a

486
00:33:18.000 --> 00:33:23.000
more, approachable way.

487
00:33:23.000 --> 00:33:28.000
>> Thank you. So on that note, I
think talking about very care,

488
00:33:28.000 --> 00:33:33.000
someone asked if, you discuss
the concept of food deserts,

489
00:33:33.000 --> 00:33:39.067
at all in that engage in those
engagement activities.

490
00:33:39.067 --> 00:33:45.067
The concept is discussed with
our trainees, and,

491
00:33:45.067 --> 00:33:50.000
I'm not sure, if it needs to be
discussed

492
00:33:50.000 --> 00:33:52.000
with some of our committee
partners, because our community
partners live

493
00:33:52.000 --> 00:33:56.000
in those areas, so, sometimes I
think we, sensitive tone as
opposed

494
00:33:56.000 --> 00:33:59.000
to lecturing work committee
partners about, what

495
00:33:59.000 --> 00:34:03.000
it is, that they experience on a
daily live. As part of their
daily

496
00:34:03.000 --> 00:34:09.000
live. Those are things that we
discussed with our, trainees so
they are sensitive

497
00:34:09.000 --> 00:34:13.000
when going into these areas,
especially in Appalachia, F
people have never

498
00:34:13.000 --> 00:34:18.000
been to Appalachia, important
people have an awareness,
engage, in

499
00:34:18.000 --> 00:34:23.000
respectful ways, in the same
way, when people go into any
community.

500
00:34:23.000 --> 00:34:28.000
That they understand, respectful
ways to engage.

501
00:34:28.000 --> 00:34:31.000
>> Great, thank you.

502
00:34:31.000 --> 00:34:35.000
>> Next question talks about
your, the pilot project, that
you mentioned,

503
00:34:35.000 --> 00:34:41.000
I think it's a question about,
is this part of your research,

504
00:34:41.000 --> 00:34:45.934
part of your training Corps, or,
does this come from one of

505
00:34:45.934 --> 00:34:48.934
the research projects?

506
00:34:48.934 --> 00:34:51.934
I think they're kind of asking
where that funding comes from,
and,

507
00:34:51.934 --> 00:34:52.934
a little bit more about those
pilot projects.

508
00:34:52.934 --> 00:34:57.934
>> Funding does come from the
training Corps it is, came up
with

509
00:34:57.934 --> 00:35:01.934
an idea from the training Corps,
project insults, answering the
trainees.

510
00:35:01.934 --> 00:35:05.934
It is, a way for them to enter
monthly training meetings

511
00:35:05.934 --> 00:35:10.934
always, interact a lot, talk
about her research. Been a way
of figuring

512
00:35:10.934 --> 00:35:16.934
out, what projects can we do,
that help answer questions
between, and

513
00:35:16.934 --> 00:35:19.934
directions of say, material
being developed on the

514
00:35:19.934 --> 00:35:25.934
engineering side how it
interacts with mice model. So,

515
00:35:25.934 --> 00:35:31.934
providing small very small,
fund, and issued those
interactions can

516
00:35:31.934 --> 00:35:36.934
become, supplement, or bigger
projects, later on. Right now
the one we

517
00:35:36.934 --> 00:35:41.000
initially funded project three
and project four, have a couple
more

518
00:35:41.000 --> 00:35:44.000
in the works. That there is one
will be bridging project

519
00:35:44.000 --> 00:35:50.000
wanted project free, being able
to do that interpret
disciplinary

520
00:35:50.000 --> 00:35:56.000
research between medical
environmental engineering
projects.

521
00:35:56.000 --> 00:35:57.000
>> Okay, thank you.

522
00:35:57.000 --> 00:36:02.000
>> There was a general question
that brought up,

523
00:36:02.000 --> 00:36:08.000
SARS-CoV-2 virus infection
morbidity, mortality from,

524
00:36:08.000 --> 00:36:11.000
virus infection help inform
epidemiology chemical exposure
for years to come,

525
00:36:11.000 --> 00:36:15.000
thinking specifically of what
kind of effect PCBs,

526
00:36:15.000 --> 00:36:20.000
adipose tissue might have on
behavior of adipose stages
during a COVID-19

527
00:36:20.000 --> 00:36:24.000
storm, PCD exposed communities,
is your

528
00:36:24.000 --> 00:36:30.000
center, looking at all, anything
related to SARS-CoV-2 and

529
00:36:30.000 --> 00:36:33.000
exposures?

530
00:36:33.000 --> 00:36:37.000
I think, this is, very
interesting study, also we

531
00:36:37.000 --> 00:36:43.067
all know strong influence on the
information, we

532
00:36:43.067 --> 00:36:46.000
this is not what we are, doing
research now, we are

533
00:36:46.000 --> 00:36:52.000
planning on our future studies,
with information, specifically
in

534
00:36:52.000 --> 00:36:58.000
the nutrition our current study,

535
00:36:58.000 --> 00:37:04.000
consuming high-fiber diet, we
know, protects against, stress

536
00:37:04.000 --> 00:37:09.000
and inflammation,

537
00:37:09.000 --> 00:37:13.000
>> Thank you.

538
00:37:13.000 --> 00:37:15.000
Another question relates your
community do you have something
else to say

539
00:37:15.000 --> 00:37:18.000
Kelly?

540
00:37:18.000 --> 00:37:23.000
>> No, that was hand, I think
we're done

541
00:37:23.000 --> 00:37:25.000
>> Okay. Great. There was
another question related to your
engagement

542
00:37:25.000 --> 00:37:31.000
activities, are there any plans,
to move beyond berries and
expanded

543
00:37:31.000 --> 00:37:33.000
to vegetables?

544
00:37:33.000 --> 00:37:36.000
>> We actually do much more than
berries just one example we
could

545
00:37:36.000 --> 00:37:44.067
squeeze in, actually we have
something called Tanglewood
walking trail,

546
00:37:44.067 --> 00:37:47.000
in addition, committee members,
this is a long-standing

547
00:37:47.000 --> 00:37:52.000
community partnership, where,
they can also at the farmers
market,

548
00:37:52.000 --> 00:37:58.000
you can choose to be part of a
walking program, walk a certain,
I believe

549
00:37:58.000 --> 00:38:03.000
it was, vouchers for the farmers
market

550
00:38:03.000 --> 00:38:08.000
there, and has been part of an
ongoing we often leverage
existing partnerships,

551
00:38:08.000 --> 00:38:13.000
we have, and then, existing
large community partnership,

552
00:38:13.000 --> 00:38:18.000
and so, then they get fresh
grown, produced at the farmers

553
00:38:18.000 --> 00:38:21.000
market, they also get, knowledge
about

554
00:38:21.000 --> 00:38:25.000
environment pollution which has
not been occurring, in that
location.

555
00:38:25.000 --> 00:38:28.000
So yes, we do, both, we don't
just do for we kind of just meet
whatever

556
00:38:28.000 --> 00:38:32.000
there is, that also whatever
committee interest there is

557
00:38:32.000 --> 00:38:36.000
for to fill those voids and
gaps, with, the community
interest, and

558
00:38:36.000 --> 00:38:41.067
continue building that. I will
say Dr. Brewer has been
excellent,

559
00:38:41.067 --> 00:38:47.000
building and nurturing, and
sustaining those committee
partnerships.

560
00:38:47.000 --> 00:38:55.000
Thank you Dr. Pennell all the
questions I see that you

561
00:38:55.000 --> 00:38:58.000
in a pot at this point it one
more minute, therapy else has
any questions,

562
00:38:58.000 --> 00:39:02.000
please submit them, in the
meantime, anybody on the phone
line have any

563
00:39:02.000 --> 00:39:07.000
questions? Before we move on.

564
00:39:07.000 --> 00:39:10.000
>> I will add one more,
community engagement thing we
have, if I have

565
00:39:10.000 --> 00:39:13.000
a chance,

566
00:39:13.000 --> 00:39:19.000
>> Go ahead. 2 we have another
thing, we do within community
engagement

567
00:39:19.000 --> 00:39:22.000
call the body balance
curriculum, this is been
published, both in

568
00:39:22.000 --> 00:39:27.000
literature, also we have a fully
published called body balance,
this

569
00:39:27.000 --> 00:39:31.000
is done now throughout Kentucky,
one of it as I mentioned,

570
00:39:31.000 --> 00:39:37.000
our waterways, we still have
quite a few people, who
actually,

571
00:39:37.000 --> 00:39:40.067
this for consumption reasons
even though our waterways,
should not

572
00:39:40.067 --> 00:39:44.067
be phished. Because, of PCBs.
So, body balance curriculum
speaks about,

573
00:39:44.067 --> 00:39:48.000
nutritional but also, about how
to protect yourself,

574
00:39:48.000 --> 00:39:53.000
against PCBs, might be present
in fish? What about environment

575
00:39:53.000 --> 00:39:59.000
pollution, that also dietary
intake intake, entrance

576
00:39:59.000 --> 00:40:01.000
very popular really,
contextualizes it for, a

577
00:40:01.000 --> 00:40:04.000
lot of interesting rural areas.

578
00:40:04.000 --> 00:40:10.000
Talks about, different all
different aspects, of, nutrition

579
00:40:10.000 --> 00:40:15.000
as well as environment
pollution, title is body
balance, that has

580
00:40:15.000 --> 00:40:18.000
been very well received. Again
we have taken a note to her
extension

581
00:40:18.000 --> 00:40:23.000
agents, can get into well all
120 counties. Received I believe
by

582
00:40:23.000 --> 00:40:28.000
over 1000 people, we expect to
ever see that education, that

583
00:40:28.000 --> 00:40:33.000
even hits on, proteins, animal
proteins,

584
00:40:33.000 --> 00:40:40.067
fruits, vegetables, that also,
environment of pollutants.

585
00:40:40.067 --> 00:40:43.067
>> Thank you.

586
00:40:43.067 --> 00:40:45.067
>> Thank you again, to the
University of Kentucky SRP
Center team really

587
00:40:45.067 --> 00:40:51.000
appreciate your presentation, we
will now move on, next,

588
00:40:51.000 --> 00:40:57.000
we will hear from the Oregon
State SRP Center, first up is
Dr. Robin

589
00:40:57.000 --> 00:40:58.000
is English Professor, Department
of

590
00:40:58.000 --> 00:41:03.000
environment and molecular
toxicology director of the
Oregon State University

591
00:41:03.000 --> 00:41:08.000
Superfund research program,
director of the Newburgh

592
00:41:08.000 --> 00:41:11.000
aquatic research repertory, OSU
environmental health sciences
center.

593
00:41:11.000 --> 00:41:17.000
Major focus of her research, on
identifying chemicals, mixers to

594
00:41:17.000 --> 00:41:18.000
produce neurotoxicity.

595
00:41:18.000 --> 00:41:24.000
Anchoring coupled with the
inherent molecular and genetic
advantages

596
00:41:24.000 --> 00:41:28.000
zebrafish to find the mechanism
with chemicals reps and
particles

597
00:41:28.000 --> 00:41:34.000
indirectly, firstly affect
vertebrate, development and.
Next up Dr.

598
00:41:34.000 --> 00:41:38.000
Tim Anderson, professor and head

599
00:41:38.000 --> 00:41:40.067
of the Department of
environmental and molecular
toxicology at Oregon

600
00:41:40.067 --> 00:41:45.067
State University. Directs food
safety, and for mental
stewardship program

601
00:41:45.067 --> 00:41:50.000
at OSU, also a project core
leader, Oregon

602
00:41:50.000 --> 00:41:52.000
State SRP Center.

603
00:41:52.000 --> 00:41:53.501
Chemicals between interfaces

604
00:41:53.501 --> 00:41:56.000
including affirmative
compartments environment

605
00:41:56.000 --> 00:41:59.000
and organism. Also a founding
member early-stage startup
company

606
00:41:59.000 --> 00:42:03.000
focused on innovative
technologies for monitoring
individual environmental

607
00:42:03.000 --> 00:42:08.000
exposure passive monitoring
devices. Finally, Dr. Susan
Pelton

608
00:42:08.000 --> 00:42:13.000
associate Professor, director
academic programs, Department of

609
00:42:13.000 --> 00:42:17.000
environment and molecular
toxicology at Oregon State.

610
00:42:17.000 --> 00:42:21.000
Research focused on using
molecular, and computational
tools to understand

611
00:42:21.000 --> 00:42:26.000
and predict, toxicity of
chemical contaminants. Current
research

612
00:42:26.000 --> 00:42:30.000
program applies, advanced cell
culture techniques to explore
mechanisms

613
00:42:30.000 --> 00:42:35.000
of toxicity and disease, and
human systems.

614
00:42:35.000 --> 00:42:41.067
Without Dr., I will not over to
you. Thank you very much
afternoon,

615
00:42:41.067 --> 00:42:42.067
good morning everybody.

616
00:42:42.067 --> 00:42:47.000
I will just get started, so our
goal here is to briefly
introduce,

617
00:42:47.000 --> 00:42:50.000
composition of our center that
we would spend, a bit more
detail on

618
00:42:50.000 --> 00:42:53.000
three of our selective products.

619
00:42:53.000 --> 00:43:00.000
Today. First, really nicely,
describe the goals

620
00:43:00.000 --> 00:43:04.000
of the SRP program, really a
problem focused program

621
00:43:04.000 --> 00:43:07.000
supports, what is the problem,
that we are trying to address,
but if

622
00:43:07.000 --> 00:43:12.000
you on the call understand,
proximally 53 million people
live within three

623
00:43:12.000 --> 00:43:17.000
miles of the Superfund site. PH
three of the top 10 of

624
00:43:17.000 --> 00:43:22.000
the ATS DR hazardous substances,
or the hundred

625
00:43:22.000 --> 00:43:27.000
parent pH compounds are known,
and, more importantly unknown
number

626
00:43:27.000 --> 00:43:33.000
of, pH derivatives metabolites
in the environment, and, where
they

627
00:43:33.000 --> 00:43:36.000
come from, as you well know,
they arise from industrial
processes,

628
00:43:36.000 --> 00:43:42.067
extraction and burning of fossil
fuels. So, pH typically exist
in,

629
00:43:42.067 --> 00:43:47.000
complex environment will mixers,
mixtures major major focus of
our

630
00:43:47.000 --> 00:43:52.000
center. Finally, substantially
higher consideration

631
00:43:52.000 --> 00:43:55.000
pHs, existent soil and water.

632
00:43:55.000 --> 00:44:01.000
So even though we were, number
of specific Superfund sites

633
00:44:01.000 --> 00:44:03.000
selected pHs, and the title of
this webinar today,

634
00:44:03.000 --> 00:44:06.000
really legacy emerging
compounds.

635
00:44:06.000 --> 00:44:12.000
PAH legacy, contaminants, but,
emerging issue

636
00:44:12.000 --> 00:44:18.000
as we better understand source
and the dynamic

637
00:44:18.000 --> 00:44:24.000
change in this PAH organisms,
what are the known

638
00:44:24.000 --> 00:44:29.000
PAH health effects, certainly,
exposure primarily the
ingestion,

639
00:44:29.000 --> 00:44:33.000
primarily most of you
understand, the risk

640
00:44:33.000 --> 00:44:38.000
PAH some PAH pose as
carcinogenic agents, and,

641
00:44:38.000 --> 00:44:44.000
because of that, known property
of some PAH, majority of
available

642
00:44:44.000 --> 00:44:48.934
research is on, EPA 16 priority
PAH clearly

643
00:44:48.934 --> 00:44:52.934
just said, in a previous like
there's hundred and hundreds of
PAH, most

644
00:44:52.934 --> 00:44:57.934
of her work really focused on,
the 16 because of their
carcinogenicity

645
00:44:57.934 --> 00:45:03.934
mounting evidence, other PAH
concern for human health.

646
00:45:03.934 --> 00:45:08.934
And a large focus, of our
center, still certainly includes
understanding

647
00:45:08.934 --> 00:45:13.934
cancer affects, also some of the
noncancer effect. As we tackle a

648
00:45:13.934 --> 00:45:16.934
more diverse group of PAH.

649
00:45:16.934 --> 00:45:20.934
So, why do we focus on PAH?

650
00:45:20.934 --> 00:45:25.934
>> Personal don't really have a
good understanding of the
mechanisms

651
00:45:25.934 --> 00:45:29.934
almost PAH interact with
biology, to produce, adverse
effects.

652
00:45:29.934 --> 00:45:34.934
I mentioned earlier, their
environmentally dynamic, PAH
some of these are,

653
00:45:34.934 --> 00:45:36.934
illustrated here.

654
00:45:36.934 --> 00:45:41.000
They exist in the environment,
they are modified, by
atmospheric

655
00:45:41.000 --> 00:45:46.000
or, microbial or biological
actions.

656
00:45:46.000 --> 00:45:51.000
Toxicity data, very scarce for
some of these derivatives, that

657
00:45:51.000 --> 00:45:54.000
are, certainly found in the
environment, Dr. Anderson will
talk

658
00:45:54.000 --> 00:46:00.000
after me about how she studies,
and, discovers this these pHs.

659
00:46:00.000 --> 00:46:06.000
We do know some pHs induce,
toxicity, through an AH
receptor,

660
00:46:06.000 --> 00:46:11.000
dependence, mechanism, others
doing independent of AHR, third

661
00:46:11.000 --> 00:46:16.000
category some that, do both,
there's a metabolism dependence

662
00:46:16.000 --> 00:46:20.000
following induction, so that is
something were trying to tackle

663
00:46:20.000 --> 00:46:25.000
or systematically. Finally I
think the biggest challenge is,

664
00:46:25.000 --> 00:46:30.000
we the entire field, sexual
basis to predict, the toxicity

665
00:46:30.000 --> 00:46:35.000
really almost any of these
tackle,

666
00:46:35.000 --> 00:46:40.067
systematic way to understand,
how any pH PAH in any system I
produce

667
00:46:40.067 --> 00:46:45.067
harm that's what were trying to
tackle. Overall mission of our
center

668
00:46:45.067 --> 00:46:50.000
really to identify, the PAH, in
the environment, characterize
their

669
00:46:50.000 --> 00:46:54.000
toxicity, using a number of
different means, then identify
the

670
00:46:54.000 --> 00:46:58.000
levels of those chemicals, in
the environment which they do
not pose

671
00:46:58.000 --> 00:47:03.000
a threat to humans. We then
plan, to supply this
information,

672
00:47:03.000 --> 00:47:08.000
EPA, other partners with
actionable information, and the
tools necessary,

673
00:47:08.000 --> 00:47:13.000
to help them make better
decisions around, remediation,

674
00:47:13.000 --> 00:47:16.000
or, guidance. To the public.

675
00:47:16.000 --> 00:47:21.000
Center aims to collect PAH

676
00:47:21.000 --> 00:47:26.000
mixers, SS toxicity, little bit
about that, with my project, Dr.

677
00:47:26.000 --> 00:47:31.000
Tilton will talk to you are
project to be able to

678
00:47:31.000 --> 00:47:36.000
predict new PAH compounds
treated as a byproduct of
remediation, Superfund

679
00:47:36.000 --> 00:47:42.067
site SS toxicity, mounting
evidence

680
00:47:42.067 --> 00:47:46.000
a little bit more careful
following, disappearance of a
parent compound,

681
00:47:46.000 --> 00:47:51.000
following remediation, pay
attention to what we created, as
a result

682
00:47:51.000 --> 00:47:55.000
of our actions. In other words,
are we making the situation

683
00:47:55.000 --> 00:48:00.000
better or worse. Kim will talk
about, deploying

684
00:48:00.000 --> 00:48:05.000
technology, a number formats, to
assess human exposure, movements

685
00:48:05.000 --> 00:48:11.000
of pH in the environment both
Susan and I, and,

686
00:48:11.000 --> 00:48:15.000
try to identify,

687
00:48:15.000 --> 00:48:19.000
network, there targeted by PAH,
actually service early
indicators

688
00:48:19.000 --> 00:48:23.000
of disease, using these early
indications of, adversity.

689
00:48:23.000 --> 00:48:27.000
That we wanted to determine how
exposure susceptibility cross

690
00:48:27.000 --> 00:48:32.000
test systems can make humans
depend on physicochemical
properties of

691
00:48:32.000 --> 00:48:35.000
PAH, tissue, body composition,
this is really

692
00:48:35.000 --> 00:48:41.067
a Justin Jordan project, trying
to link actual,

693
00:48:41.067 --> 00:48:45.067
movement of these compounds
across systems, and, are we
studying for

694
00:48:45.067 --> 00:48:49.000
example, toxicity of PAH
concentrations which are

695
00:48:49.000 --> 00:48:53.000
most relevant for humans, major
focus there ground troops
research.

696
00:48:53.000 --> 00:48:59.000
This is kind of a placement
version of our,

697
00:48:59.000 --> 00:49:02.000
center I will just briefly go
over, we have, five projects
which are

698
00:49:02.000 --> 00:49:05.000
listed here on the right, so,
Dr.

699
00:49:05.000 --> 00:49:08.000
Susan Tilton, leads the project
she will describe,

700
00:49:08.000 --> 00:49:13.000
and then, Justin and Jordan,
lead the project focused on
elucidating,

701
00:49:13.000 --> 00:49:17.000
metabolic chemical mechanisms,
PAH susceptibility,

702
00:49:17.000 --> 00:49:23.000
test system humans, then, Lisa
codirects,

703
00:49:23.000 --> 00:49:27.000
project I will describe in a
second, Kim Anderson, describes,
so, describe

704
00:49:27.000 --> 00:49:31.000
the project of evaluating
technology to measure

705
00:49:31.000 --> 00:49:36.000
PAH states, and exposures.
Finally, response to the mandate
for, for

706
00:49:36.000 --> 00:49:42.067
the Superfund research program,
Dr. semitic,

707
00:49:42.067 --> 00:49:46.000
focusing on, understanding PAH,
that, how to

708
00:49:46.000 --> 00:49:50.000
transform, under various
remediation conditions, trying
to protect resulting

709
00:49:50.000 --> 00:49:56.000
metabolites, derivatives
letterform,

710
00:49:56.000 --> 00:50:00.000
working with the rest of the
center identifying whether this
compounds

711
00:50:00.000 --> 00:50:07.000
are, biologically a problem.
And, we have us administrative
core,

712
00:50:07.000 --> 00:50:12.000
VRS one how the NS2 works, this
is really central to our center,

713
00:50:12.000 --> 00:50:17.000
really the lifeline of the data
that flows,

714
00:50:17.000 --> 00:50:20.000
into and out of projects, and,
to our stakeholders

715
00:50:20.000 --> 00:50:28.000
treat waters, community
engagement core

716
00:50:28.000 --> 00:50:33.000
really, our working with our
tribal partners, and, maybe,

717
00:50:33.000 --> 00:50:37.000
future webinars, we will hear
from the other half of our
center. And

718
00:50:37.000 --> 00:50:43.067
then, Kim, director chemical
mixtures core, essential core

719
00:50:43.067 --> 00:50:48.000
four, analysis, and tissue
assessments, of pHs. Finally,

720
00:50:48.000 --> 00:50:52.000
our trainees, our, really nicely
supported, by

721
00:50:52.000 --> 00:50:55.000
experience investigators Dr.

722
00:50:55.000 --> 00:51:02.000
Craig Marcus, and, again, we
will talk about that in another
time.

723
00:51:02.000 --> 00:51:08.000
So, will he wanted to show,
center integration, certainly
the

724
00:51:08.000 --> 00:51:12.000
goal of our programs, across all
of the funded centers, across
all

725
00:51:12.000 --> 00:51:18.000
of the crunching country. Center
isn't just integrated, it is
highly

726
00:51:18.000 --> 00:51:23.000
interdependent, so again, on the
outside here you see the, five
projects,

727
00:51:23.000 --> 00:51:26.000
that are, briefly described, and
there supported

728
00:51:26.000 --> 00:51:32.000
by, our course perimeter. Then,
we have our, most importantly
our

729
00:51:32.000 --> 00:51:36.000
trainees, trainees was that get
everything done, goal

730
00:51:36.000 --> 00:51:40.067
of all of the leaders and these
components related support, our

731
00:51:40.067 --> 00:51:45.067
trainees. So, I just want to
swing very quickly

732
00:51:45.067 --> 00:51:50.000
details on, project that Lisa
and I direct, predicting
toxicity of

733
00:51:50.000 --> 00:51:54.000
complex PAH mixtures and so,
really those

734
00:51:54.000 --> 00:51:58.000
of this project are, determine
how the develop mental impacts
PAH exposures

735
00:51:58.000 --> 00:52:01.000
depend on the composition of the
mixtures, and, chemical
structures

736
00:52:01.000 --> 00:52:07.000
of environmentally transformed
PAHs, this kind of a mouthful
basically

737
00:52:07.000 --> 00:52:12.000
you can imagine returning her
hands on as many complex

738
00:52:12.000 --> 00:52:16.000
mixtures of PAHs we can define,
number of individual PAHs, and,

739
00:52:16.000 --> 00:52:24.000
directly compare them
side-by-side, in a common
system. We, work across

740
00:52:24.000 --> 00:52:28.000
standards measure the uptake
biologically active PAHs, wanted

741
00:52:28.000 --> 00:52:34.000
about agnostic pathways,
declassified PAHs, how these
pathways

742
00:52:34.000 --> 00:52:39.067
functions does, then, finally
want to determine adult

743
00:52:39.067 --> 00:52:42.067
and transgenerational
consequences following transient
development

744
00:52:42.067 --> 00:52:46.000
exposures individual PAHs model
mixtures. How do we

745
00:52:46.000 --> 00:52:52.000
do this, comparative assessment,
working with Dr. Anderson,
chemical

746
00:52:52.000 --> 00:52:57.000
mixtures core we got her hands
on, number PAHs very

747
00:52:57.000 --> 00:53:02.000
in the number of rings. From,
2-7. and, then various

748
00:53:02.000 --> 00:53:08.000
forms of it, so either,
heterocyclic Knight-Ridder,

749
00:53:08.000 --> 00:53:15.000
we just, collected them, we
didn't,

750
00:53:15.000 --> 00:53:19.000
really didn't know what hardly
any of these PAHs might do in a
biological

751
00:53:19.000 --> 00:53:23.000
system, wanted to get them
validated them, deliver our
laboratory. And,

752
00:53:23.000 --> 00:53:28.000
really what we wanted to do we,
decided it would be, really nice

753
00:53:28.000 --> 00:53:33.000
to have, all of the data come
from all of these,

754
00:53:33.000 --> 00:53:39.067
confirmed PAHs, tested in one,
system and so in the system,
uses zebrafish

755
00:53:39.067 --> 00:53:43.067
you know me you for this the
story 1000 times, we really

756
00:53:43.067 --> 00:53:47.000
take advantage of this dynamic
nature of really complex
biology, we

757
00:53:47.000 --> 00:53:53.000
do our exposures from, six
hours, post fertilization,
continuously

758
00:53:53.000 --> 00:53:57.000
until, larval phase here,
hundred and

759
00:53:57.000 --> 00:54:00.000
20 our HPF, we basically our
challenge animal to develop
normally, in the

760
00:54:00.000 --> 00:54:06.000
presence of increasing
concentrations of these
individual PAHs.

761
00:54:06.000 --> 00:54:11.000
Multiple replicates, do 32
animals at every concentration.
And, we,

762
00:54:11.000 --> 00:54:16.000
do multiple replicates plates,
the things we do, we measure
early,

763
00:54:16.000 --> 00:54:21.000
evidence of destruction of
behavioral, phenotypes,

764
00:54:21.000 --> 00:54:25.000
a number of, what we call
morphological effects, at five
days, then we,

765
00:54:25.000 --> 00:54:30.000
look at a number of other
behavioral assessments, at five
days, animals

766
00:54:30.000 --> 00:54:34.000
have gone from this, single cell
stage, way back here

767
00:54:34.000 --> 00:54:40.000
at zero, HPF to this really
complicated organism just five
days, in addition

768
00:54:40.000 --> 00:54:45.000
to all of this data, also do
chemistry, to see whether or
not,

769
00:54:45.000 --> 00:54:50.934
P4 51 a has been induced,
evidence of HR to activation.

770
00:54:50.934 --> 00:54:53.934
This is what you look at, at the
end of

771
00:54:53.934 --> 00:54:59.934
looking at the biomarker or the
induction of, sip one a,

772
00:54:59.934 --> 00:55:05.934
what we see as examples, we
have, no evidence

773
00:55:05.934 --> 00:55:10.934
of, induction, induction of, can
ministry for the antibody,

774
00:55:10.934 --> 00:55:16.934
protein. We see evidence, skin
is, expressing,

775
00:55:16.934 --> 00:55:21.934
be 54 one a, and/or the neural
mass, vascular this example,

776
00:55:21.934 --> 00:55:26.934
then we see that area, examples
of the skin,

777
00:55:26.934 --> 00:55:30.934
this is just an example of, six
different PAHs, that behave
differently

778
00:55:30.934 --> 00:55:35.934
in terms of this, really
invaluable way to classify

779
00:55:35.934 --> 00:55:38.934
PAHs.

780
00:55:38.934 --> 00:55:43.000
This is a ton of data just going
to show you really quickly,

781
00:55:43.000 --> 00:55:46.000
you can't read any of it I know,
what you see down here a number

782
00:55:46.000 --> 00:55:51.000
of PAHs, hundred and 27 PAHs
here,. All the endpoints we
assess

783
00:55:51.000 --> 00:55:56.000
also look at, whether where, and
when, CYP1A

784
00:55:56.000 --> 00:56:00.000
is expressed anywhere we see
white, nothing happened. We look
very

785
00:56:00.000 --> 00:56:04.000
carefully, we see, no sex, no
gene expression in this

786
00:56:04.000 --> 00:56:09.000
example, for every bright red
color, a low concentration,
given PAH,

787
00:56:09.000 --> 00:56:14.000
has, cause this effect. So what
were doing,

788
00:56:14.000 --> 00:56:17.000
we are, looking at all these
PAHs, this

789
00:56:17.000 --> 00:56:21.000
example we cluster them based on
where the 450 was induced,
that's

790
00:56:21.000 --> 00:56:24.000
for you see the's clustering's
here.

791
00:56:24.000 --> 00:56:28.000
And then, we are seeing whether
or not there's a relationship,
between

792
00:56:28.000 --> 00:56:32.000
these activities, various effect
of these PAHs, whole

793
00:56:32.000 --> 00:56:35.000
animal system and, the
structure.

794
00:56:35.000 --> 00:56:38.000
Again that is kind of the basis
of, these groupings. Similar

795
00:56:38.000 --> 00:56:43.067
EPA does, try to fight common
action, try to do this for
hundreds and

796
00:56:43.067 --> 00:56:49.000
hundreds of individual PAHs.
Just a final, then I want to
point out

797
00:56:49.000 --> 00:56:53.000
talk a little bit about this in
her project as well, is, in
addition

798
00:56:53.000 --> 00:56:56.000
to looking at these whole animal
responses, use a lot

799
00:56:56.000 --> 00:57:02.000
of whole animal sequencing
analysis, example, some various

800
00:57:02.000 --> 00:57:07.000
PAHs here, doing hole, hole,

801
00:57:07.000 --> 00:57:12.000
unbiased whole organism holds
human what you do is we start
getting

802
00:57:12.000 --> 00:57:17.000
these patterns, gene expression
actually correlate with the
biological

803
00:57:17.000 --> 00:57:21.000
we see, further helping us to
have confidence

804
00:57:21.000 --> 00:57:25.000
that, PAH cause the same effect,
any and

805
00:57:25.000 --> 00:57:28.000
all, and produce the same
expression changes, truly are
behaving the

806
00:57:28.000 --> 00:57:33.000
same way biologically. From a
type of an approach, might be
able to

807
00:57:33.000 --> 00:57:35.000
these PAHs.

808
00:57:35.000 --> 00:57:39.067
Finally, I don't have time to
talk about this today, also
doing a lot

809
00:57:39.067 --> 00:57:45.067
of, early lifetime exposures,
concentrations which are closer
to, achievement

810
00:57:45.067 --> 00:57:52.000
levels of exposure, assessing
transient impact, of these

811
00:57:52.000 --> 00:57:54.000
exposures on, adult phenomenon,
swimming activity, anxiety,
aggression,

812
00:57:54.000 --> 00:57:56.000
social interactions and
learning.

813
00:57:56.000 --> 00:57:59.000
Can we tease out these really
complex effects of PAHs, the
answer is yes

814
00:57:59.000 --> 00:58:03.000
we can hear more about that in
the future years. So, before
heading

815
00:58:03.000 --> 00:58:08.000
off to Kim really want to
acknowledge certainly, the
Superfund research

816
00:58:08.000 --> 00:58:13.000
program director the program,
Daniel, administered, and, here

817
00:58:13.000 --> 00:58:19.000
is our grant number, really most
important, in-house, Sean Tucker

818
00:58:19.000 --> 00:58:21.000
program manager, many of you
have worked with him, Lisa

819
00:58:21.000 --> 00:58:26.000
Sheppard finance manager Mike
Barton is our, data systems
manager

820
00:58:26.000 --> 00:58:34.000
moving the data within, the
administered of core.

821
00:58:34.000 --> 00:58:38.000
And we will head off to camp
next, but, if you need further
information

822
00:58:38.000 --> 00:58:41.067
I know you have the webinar, as
well you can reach me by email
here,

823
00:58:41.067 --> 00:58:45.067
here is more information on our
center. With that I will take
any

824
00:58:45.067 --> 00:58:55.000
questions. Move on to Kim.

825
00:58:55.000 --> 00:58:57.000
>> Thank you doctor I think will
take questions at the end of
your

826
00:58:57.000 --> 00:59:00.000
Centris presentation.

827
00:59:00.000 --> 00:59:03.000
>> Yes, that is fine.

828
00:59:03.000 --> 00:59:07.000
Sure hi everyone, my, working
off of, some of the things

829
00:59:07.000 --> 00:59:14.000
Robin told you about, our center
first of our work is actually
understand

830
00:59:14.000 --> 00:59:19.000
movement of chemicals, we can,
implement some of our other
study so, first

831
00:59:19.000 --> 00:59:24.000
quarter talk about assessing PAH
movement, and, you will see
hopefully

832
00:59:24.000 --> 00:59:29.000
the implications exposure,
remediation, intervention, so

833
00:59:29.000 --> 00:59:34.000
actually three field campaigns,
in the last year. You can see
some

834
00:59:34.000 --> 00:59:39.067
of our, fieldwork actually
takes, three different tracks

835
00:59:39.067 --> 00:59:44.067
lots of deer that goes out, it's
a big operation, go in the
field.

836
00:59:44.067 --> 00:59:48.000
Talking about PAH, movement and,
affects on the assessment

837
00:59:48.000 --> 00:59:54.000
of exposures remediation, and
interventions, we actually

838
00:59:54.000 --> 00:59:58.000
devices, both in the field, and,
diverse

839
00:59:58.000 --> 01:00:03.000
hands on folks, animals, that is
to try to capture that bio
available

840
01:00:03.000 --> 01:00:06.000
traction of PAH and the
environment along with post

841
01:00:06.000 --> 01:00:12.000
of other organic chemicals
mixture beyond the mixers of

842
01:00:12.000 --> 01:00:16.000
PAHs, certainly even, we know
that, PAH moving constantly,

843
01:00:16.000 --> 01:00:22.000
environment even when there so
we've seen, this within our
group,

844
01:00:22.000 --> 01:00:28.000
others, have seen it changes,
seasonally,

845
01:00:28.000 --> 01:00:32.000
how will those changes actually
affect the movement between,
individual

846
01:00:32.000 --> 01:00:35.000
compartments like air, water,
important to understanding,
exposure

847
01:00:35.000 --> 01:00:41.067
remediation prevention. We also,
have diffusion PAHs,

848
01:00:41.067 --> 01:00:46.000
bioavailable diffusion PAHs,
between these departments,

849
01:00:46.000 --> 01:00:51.000
speculated of the component,

850
01:00:51.000 --> 01:00:57.000
even look at, movement of,
chemicals from sediments to
water, actually

851
01:00:57.000 --> 01:01:01.000
at that in, how can we add that
in, really

852
01:01:01.000 --> 01:01:04.000
wasn't a lot of, technical
abilities to do that from a past
standpoint,

853
01:01:04.000 --> 01:01:10.000
perspective we had actually
developed testing technology
there, to

854
01:01:10.000 --> 01:01:13.000
do this past sampling, process.

855
01:01:13.000 --> 01:01:18.000
So here, is one of our sites in
northern Oregon, and you can

856
01:01:18.000 --> 01:01:24.000
sort of see ribbon array, of
samplers from upriver to
downriver,

857
01:01:24.000 --> 01:01:30.000
left to right bottom to top, we
sampled, multiple times summer,

858
01:01:30.000 --> 01:01:34.000
into summer fall, plus your

859
01:01:34.000 --> 01:01:37.000
about this time last year
actually.

860
01:01:37.000 --> 01:01:42.067
Pulling samples, out we had 150

861
01:01:42.067 --> 01:01:47.000
sampling devices, and we are
looking for, lots and lots of,
PAHs as Robin

862
01:01:47.000 --> 01:01:50.000
mentioned looking for, several
hundred PAHs, substituted

863
01:01:50.000 --> 01:01:56.000
PAHs, and, other chemicals in
these samplers. Just going to
talk

864
01:01:56.000 --> 01:01:59.000
about, a few this morning.

865
01:01:59.000 --> 01:02:04.000
So, to give you kind of a sense
again of the size, creosote

866
01:02:04.000 --> 01:02:09.000
side, agency land portion, has
been some remediation,
remediation

867
01:02:09.000 --> 01:02:15.000
ongoing, anticipated, they will
be a big effort,

868
01:02:15.000 --> 01:02:21.000
and 2021. into 2021 2022
actually really, poised well to

869
01:02:21.000 --> 01:02:26.000
look at, FY for remediation,
giving a presentation,

870
01:02:26.000 --> 01:02:32.000
tomorrow, on our findings,
working with consultants,

871
01:02:32.000 --> 01:02:36.000
on this side, further
understand, movement of

872
01:02:36.000 --> 01:02:42.067
chemicals. Again just to get
oriented, we have upriver on the
left, different

873
01:02:42.067 --> 01:02:47.000
sort of types of areas,

874
01:02:47.000 --> 01:02:53.000
the reason I, draw your
attention such a great site, for
a host

875
01:02:53.000 --> 01:02:56.000
of reasons, one of those going
to be remediating, in the

876
01:02:56.000 --> 01:03:02.000
middle of the study, also
because, we have really
different kinds

877
01:03:02.000 --> 01:03:08.000
of sentiments, we go from,
upstream, literally, it is,

878
01:03:08.000 --> 01:03:14.000
thigh deep, mad and Silt, then
we go down to

879
01:03:14.000 --> 01:03:20.000
like, sure not sure, it's Rick
gigantic,

880
01:03:20.000 --> 01:03:25.000
very little sediment, beginning
of a

881
01:03:25.000 --> 01:03:33.000
lot of different kinds of,
bedrock,

882
01:03:33.000 --> 01:03:37.000
sold bedrock very,
heterogeneous, very different
types of sediment,

883
01:03:37.000 --> 01:03:43.067
and especially site. So, we have
known for some time, music,

884
01:03:43.067 --> 01:03:47.000
and that there's effects, and,
these compartments

885
01:03:47.000 --> 01:03:52.000
oh, for instance lots of people
who measure, changes in temporal

886
01:03:52.000 --> 01:03:56.000
so, the air increases, on
average 25% for all PAHs,

887
01:03:56.000 --> 01:04:02.000
roughly summer and fall of is a,
heating happens air is, further

888
01:04:02.000 --> 01:04:08.000
impacted by, burning of fossil
fuels, et cetera, water decrease

889
01:04:08.000 --> 01:04:14.000
probably, due to dilution from
rain, so forth, sediment
changes.

890
01:04:14.000 --> 01:04:20.000
How does this affect movement of
chemicals is not known actually,

891
01:04:20.000 --> 01:04:24.000
static changes, how does

892
01:04:24.000 --> 01:04:28.000
that affect actual movement,
that's what were interested in
looking

893
01:04:28.000 --> 01:04:31.000
at. So, we set up trouble
sending pictures, or have

894
01:04:31.000 --> 01:04:37.000
been bit many pictures as
technology set up the series of

895
01:04:37.000 --> 01:04:43.000
objectives is used on the
cartoon, slide

896
01:04:43.000 --> 01:04:48.934
to go. Flux, movement of,
chemicals with movement of
water,

897
01:04:48.934 --> 01:04:52.934
so we have flux water, water,
and that water

898
01:04:52.934 --> 01:04:58.934
moves, with chemicals in it, how
does that, affect

899
01:04:58.934 --> 01:05:03.934
the change, movement of
chemicals, of course, is
diffusion.

900
01:05:03.934 --> 01:05:08.934
So, diffusion, from her
concentration to lower
concentrations diffusion

901
01:05:08.934 --> 01:05:13.934
can happen sediment, water air
interface, have time to talk

902
01:05:13.934 --> 01:05:18.934
about the water air interface
very interesting but, just
talking a

903
01:05:18.934 --> 01:05:24.934
little bit about the objective
to mechanisms, as I said, at the

904
01:05:24.934 --> 01:05:30.934
outset movement of chemicals,
what has always been, you

905
01:05:30.934 --> 01:05:34.934
know, speculated a big piece of
the chemical movement,

906
01:05:34.934 --> 01:05:41.000
what we see, most PAHs, moving
from the sediments reversal,
when

907
01:05:41.000 --> 01:05:46.000
you see a bar above zero, moving
from ground to water, we see,
bars

908
01:05:46.000 --> 01:05:52.000
that are, below, negative that
means, flux is going in the
other direction,

909
01:05:52.000 --> 01:05:57.000
most sites we see, at least in
this less,

910
01:05:57.000 --> 01:06:00.000
flux, info, compared to summer.

911
01:06:00.000 --> 01:06:04.000
And, might be hard depending on
the

912
01:06:04.000 --> 01:06:07.000
size of your screen, you can see
there's a scale break. There's a

913
01:06:07.000 --> 01:06:12.000
big difference in affect between
science, certainly very
important,

914
01:06:12.000 --> 01:06:17.000
to understand remediation,
consideration, so in fact see
that,

915
01:06:17.000 --> 01:06:22.000
upriver, even in, for for we
have some of those

916
01:06:22.000 --> 01:06:27.000
close to the Peninsula, very,
very small amounts,

917
01:06:27.000 --> 01:06:31.000
you can see from the scale break
where as if you go down all the

918
01:06:31.000 --> 01:06:37.000
way to the other and like urine
hundreds, versus, one.

919
01:06:37.000 --> 01:06:43.067
Milligram per meter squared, per
day. So,

920
01:06:43.067 --> 01:06:46.000
at effective, mostly diffuse
into the water, a little less
than

921
01:06:46.000 --> 01:06:52.000
the full, big differences
between let's talk about

922
01:06:52.000 --> 01:06:57.000
what I have shown two specific
PAHs here loved all the PAHs,

923
01:06:57.000 --> 01:07:03.000
to drill down, individual PAHs,
here

924
01:07:03.000 --> 01:07:08.000
very similar, and a sense of,
sticking to the PAHs as a whole,

925
01:07:08.000 --> 01:07:12.000
what we see with diffusive of
chemicals, not the water,
diffusion

926
01:07:12.000 --> 01:07:17.000
I concentration low
concentration, again, we see a
big difference,

927
01:07:17.000 --> 01:07:23.000
between sites, for these and,
other PAHs, dimensionally

928
01:07:23.000 --> 01:07:28.000
so, again see a scale change,
how

929
01:07:28.000 --> 01:07:34.000
huge the scale break is here,
so, or still seeing diffusive
flex,

930
01:07:34.000 --> 01:07:39.067
at some sites, quite large and,
other sites

931
01:07:39.067 --> 01:07:46.000
quite small, most sites, most
sites not all, most PAHs, from
the

932
01:07:46.000 --> 01:07:50.000
water, less diffusion, in the
fall, actually you don't see air

933
01:07:50.000 --> 01:07:56.000
bars yet, were working on the
propagation of air, run
replicates,

934
01:07:56.000 --> 01:08:03.000
propagation of air through the
process, still doing those
calculations.

935
01:08:03.000 --> 01:08:08.000
So, I'm not giving a statistical
uses here, we will have that

936
01:08:08.000 --> 01:08:13.000
small but more changes in
diffusion between summer and
fall.

937
01:08:13.000 --> 01:08:19.000
Big question, read, what was he
contribution, of abductive

938
01:08:19.000 --> 01:08:24.000
to the movement of chemicals
just picked

939
01:08:24.000 --> 01:08:30.000
three three, PAHs to show you,

940
01:08:30.000 --> 01:08:35.000
one vessel, flooring, and, which
is,

941
01:08:35.000 --> 01:08:39.067
to of the ones that you should
you, previous slide. Summer on
the,

942
01:08:39.067 --> 01:08:45.067
left, fall on the right. What
you see, without is, the water,

943
01:08:45.067 --> 01:08:53.000
sediment diffusion, is, huge,
dominating,

944
01:08:53.000 --> 01:08:57.000
the flux, movement of chemicals,
at the sites. For

945
01:08:57.000 --> 01:09:03.000
the most part, you can see, that
info, due to do start to see
have

946
01:09:03.000 --> 01:09:09.000
time to talk about, the air,
peace the air water

947
01:09:09.000 --> 01:09:15.000
diffusion flux PAHs, and fall,
having fossil fuels, so

948
01:09:15.000 --> 01:09:20.000
forth, you make to make a
showing here, so we are actually

949
01:09:20.000 --> 01:09:23.000
sampling, later this month no,
later November

950
01:09:23.000 --> 01:09:29.000
sampling in November, and
December, and, hope to

951
01:09:29.000 --> 01:09:35.000
further explore, the other
seasons, and, replicate

952
01:09:35.000 --> 01:09:41.067
these, analyses so, with that,
lots of people think this is, a

953
01:09:41.067 --> 01:09:47.000
big effort, as you can see, lots
of people in the field, a

954
01:09:47.000 --> 01:09:53.000
trainee, in our group, and, a
lot of folks who have,

955
01:09:53.000 --> 01:09:59.000
I need to think, including, my
staff, Ricky Scott, and,

956
01:09:59.000 --> 01:10:03.000
Lane, my fieldwork, one of my
senior staff,

957
01:10:03.000 --> 01:10:09.000
a host of, graduate students
work on this, in combination, in

958
01:10:09.000 --> 01:10:13.000
for example, taking some of
these very samples up to

959
01:10:13.000 --> 01:10:18.000
the site integrating them into
the effects directly analysis.
The zebrafish

960
01:10:18.000 --> 01:10:23.000
model. We will be putting
wristbands, with folks,

961
01:10:23.000 --> 01:10:29.000
in this area, mediation, working
with, Diana Willman, Superfund

962
01:10:29.000 --> 01:10:34.000
group, others, to implement
that, first

963
01:10:34.000 --> 01:10:39.067
part I think is really movement
of chemicals, not, sort of a one

964
01:10:39.067 --> 01:10:48.801
size picture, one day of
sampling. So again, thank you.

965
01:10:48.801 --> 01:10:54.000
>> All right thank you, Robin

966
01:10:54.000 --> 01:11:01.000
and Kim, I everyone I am Susan
Tilton

967
01:11:01.000 --> 01:11:07.000
I'm a lead of a new project,
funded as part of the OSU,
Superfund research

968
01:11:07.000 --> 01:11:10.000
program, remove this year.

969
01:11:10.000 --> 01:11:15.000
Going to give you, brief
overview, some of the plans, we
have for this

970
01:11:15.000 --> 01:11:18.000
project.

971
01:11:18.000 --> 01:11:22.000
The goal of this project to
understand how PAHs, contribute

972
01:11:22.000 --> 01:11:26.000
to toxicity and mixtures,
establish a relationship,
between

973
01:11:26.000 --> 01:11:31.000
chemical exposure, and toxicity,
human lung model.

974
01:11:31.000 --> 01:11:37.000
Collaboration with other
investigators, in our center
project broadly proposes,

975
01:11:37.000 --> 01:11:41.067
quantify the toxicity of
individual PAHs, PAH

976
01:11:41.067 --> 01:11:45.067
mixtures, in our lung culture
system, assess the role

977
01:11:45.067 --> 01:11:51.000
of metabolism, on the toxicity
of individual PAHs

978
01:11:51.000 --> 01:11:57.000
identified mechanisms of TH PAH
toxicity

979
01:11:57.000 --> 01:12:00.000
adverse outcomes.

980
01:12:00.000 --> 01:12:04.000
To assess, toxicity PAHs,
mixtures, we are utilizing

981
01:12:04.000 --> 01:12:09.000
primary human bronchial
epithelial cells, cultured at
the air liquid

982
01:12:09.000 --> 01:12:11.000
interface, which they're
differentiated to

983
01:12:11.000 --> 01:12:15.000
former multicellular
three-dimensional structure
mimics the lining, of

984
01:12:15.000 --> 01:12:19.000
the bronchial epithelial. We
have, the benefits being able to

985
01:12:19.000 --> 01:12:24.000
leverage, prior zebrafish
screening data, for over hundred

986
01:12:24.000 --> 01:12:29.000
and 80 PAHs, along with numerous
mixtures, selected as part of
the

987
01:12:29.000 --> 01:12:37.000
Superfund program within the
Tanguay project,

988
01:12:37.000 --> 01:12:40.067
Dr. Anderson's chemical Mr.
core.

989
01:12:40.067 --> 01:12:45.067
Prioritize texting, in our model
testing in our model. Across
multiple

990
01:12:45.067 --> 01:12:51.000
endpoints identify threshold
responses

991
01:12:51.000 --> 01:13:00.000
identify those are likely can
shooting toxicity.

992
01:13:00.000 --> 01:13:06.000
It is management analysis core,

993
01:13:06.000 --> 01:13:11.000
we will also model, PAH chemical
interactions across

994
01:13:11.000 --> 01:13:16.000
to inform, how individual PAHs
contribute within

995
01:13:16.000 --> 01:13:21.000
a mixture. We can use these
data, to assess,

996
01:13:21.000 --> 01:13:26.000
toxicity exposures, identified
from passive sampling, or
pre-and

997
01:13:26.000 --> 01:13:27.634
post remediation, collected as

998
01:13:27.634 --> 01:13:30.000
part of our program
environmental science

999
01:13:30.000 --> 01:13:37.000
and engineering project. This
includes, Dr. Anderson's project
you just

1000
01:13:37.000 --> 01:13:40.067
heard about, and also Dr.

1001
01:13:40.067 --> 01:13:46.000
Simonich and Dr. -- Remediation
project also,

1002
01:13:46.000 --> 01:13:49.000
samples being collected, using
these technologies, part

1003
01:13:49.000 --> 01:13:55.000
of our community engagement
forum.

1004
01:13:55.000 --> 01:14:02.000
One thing we are currently
working on, in collaboration
with

1005
01:14:02.000 --> 01:14:04.000
Anderson project, others within
the program to develop methods
and

1006
01:14:04.000 --> 01:14:10.000
approaches, for creating
sufficiently similar testing.

1007
01:14:10.000 --> 01:14:12.000
This is, is a need within our
project, and,

1008
01:14:12.000 --> 01:14:15.000
program overall to think about,
different ways in which mixtures

1009
01:14:15.000 --> 01:14:18.000
are formed for testing across
the different model systems.
Currently

1010
01:14:18.000 --> 01:14:21.000
there's a lack of an established
framework, forming sufficiently

1011
01:14:21.000 --> 01:14:27.000
similar mixtures from
environment exposure data.
Characterize, hazard

1012
01:14:27.000 --> 01:14:28.000
of exposure contaminated sites.

1013
01:14:28.000 --> 01:14:32.000
We are exploring, several
approaches, including methods
that focus, on

1014
01:14:32.000 --> 01:14:38.000
relative abundance of chemicals,
or unavailability, or
unavailable

1015
01:14:38.000 --> 01:14:42.000
toxicity data. For components,
combination of these methods.
Form sufficiently

1016
01:14:42.000 --> 01:14:47.934
similar mixtures, can be used
also talks logical evaluation.
These

1017
01:14:47.934 --> 01:14:51.934
mixtures, here, in this case,

1018
01:14:51.934 --> 01:14:55.934
I'm discovering the development
of sufficiently similar mixtures

1019
01:14:55.934 --> 01:15:01.934
associated with, legacy creosote
site, Pacific Northwest

1020
01:15:01.934 --> 01:15:06.934
Dr.-- has been working with
these the first, focus on, model

1021
01:15:06.934 --> 01:15:10.934
PAH chemical interactions, help
us understand if PAHs contribute

1022
01:15:10.934 --> 01:15:18.934
to toxicity in an manner.

1023
01:15:18.934 --> 01:15:23.934
Long-term our project, we will
identify Gina metabolic
signatures linked

1024
01:15:23.934 --> 01:15:30.934
to toxicity in our culture
model, lab has been working to
identify

1025
01:15:30.934 --> 01:15:33.934
signatures, predictive of cancer
risk, for PAHs in lung cells we

1026
01:15:33.934 --> 01:15:36.934
know, we can use these, quote
unquote chemical fingerprint to
link to

1027
01:15:36.934 --> 01:15:43.000
adverse outcomes assess
mechanisms PAH toxicity. In
particular, interested

1028
01:15:43.000 --> 01:15:49.000
to use our, culture model to
test the hypothesis

1029
01:15:49.000 --> 01:15:55.000
that, specific polymorphisms
for, phase one and phase two

1030
01:15:55.000 --> 01:15:58.000
metabolism enzymes, increase us
the ability to toxicity

1031
01:15:58.000 --> 01:16:01.000
and disease after PAH exposure.

1032
01:16:01.000 --> 01:16:06.000
In fact project explores role of
metabolism

1033
01:16:06.000 --> 01:16:11.000
PAH toxicity, inorganic culture
models, leverage the fact

1034
01:16:11.000 --> 01:16:15.000
these bottles contain metabolic
competency to evaluate the
extent

1035
01:16:15.000 --> 01:16:19.000
metabolism and cells,
contribution to toxicity.

1036
01:16:19.000 --> 01:16:24.000
So we are working closely with
our colleagues, at Pacific
Northwest

1037
01:16:24.000 --> 01:16:30.000
national labs, from Gordon Smith
project, to measure PAH uptake

1038
01:16:30.000 --> 01:16:33.000
alkylation center model.

1039
01:16:33.000 --> 01:16:39.067
In parallel, with studies, that
were described by,

1040
01:16:39.067 --> 01:16:44.067
Robin Tanguay, used to develop

1041
01:16:44.067 --> 01:16:52.000
physiologically based kinetic
models, 3-D long Dr.

1042
01:16:52.000 --> 01:16:54.000
Gardens team, that will help us
to better understand, exposure,

1043
01:16:54.000 --> 01:16:58.000
toxicity for structural diverse
PAHs our system. Ultimately will

1044
01:16:58.000 --> 01:17:02.000
be able use use this data link
concentrations of

1045
01:17:02.000 --> 01:17:06.000
PAHs measured environment from
passive sampling, concentrations
of PAHs

1046
01:17:06.000 --> 01:17:11.000
the cause, toxicity in our
model, by reverse

1047
01:17:11.000 --> 01:17:14.000
symmetry, to help inform the
public about potential risks of
respiratory

1048
01:17:14.000 --> 01:17:20.000
toxicity from exposures and
committees in a Superfund site.

1049
01:17:20.000 --> 01:17:25.000
So. With that, what a thank you,
and, I believe,

1050
01:17:25.000 --> 01:17:28.000
Dr.

1051
01:17:28.000 --> 01:17:31.000
Tanguay, Anderson, and I can
take questions

1052
01:17:31.000 --> 01:17:34.000
from the group.

1053
01:17:34.000 --> 01:17:38.000
>> Thank you Dr. Tanguay, Dr.
Anderson

1054
01:17:38.000 --> 01:17:42.067
and Dr. Tilton for your
presentation in the interest of
time I will

1055
01:17:42.067 --> 01:17:44.067
ask one or two quick questions,
then certainly pass along,
additional

1056
01:17:44.067 --> 01:17:49.000
questions to you as well, the
first question, is you have an

1057
01:17:49.000 --> 01:17:53.000
estimation of, particle bound
PAHs into

1058
01:17:53.000 --> 01:17:57.000
sentiment, also, while you were
looking at hundreds of PAH's

1059
01:17:57.000 --> 01:18:02.000
which was actually dominate the
usual suspects such as hiring,
or

1060
01:18:02.000 --> 01:18:07.000
others? Sure I guess the
questions for me, yeah,

1061
01:18:07.000 --> 01:18:13.000
we watch we do, know that
ultimately, a lot of these

1062
01:18:13.000 --> 01:18:17.000
PAHs particular matter, we don't
actually measure the particulate

1063
01:18:17.000 --> 01:18:22.000
matter because we are really
looking at, the movement of
chemicals, so,

1064
01:18:22.000 --> 01:18:28.000
we haven't looked at sediment
bound, what

1065
01:18:28.000 --> 01:18:32.000
are the issues with sediment
bound, once PAHs absorbed to

1066
01:18:32.000 --> 01:18:37.000
sediment for long periods of
time, actually become less and
less bioavailable,

1067
01:18:37.000 --> 01:18:40.067
so we have always focused on the
bioavailable

1068
01:18:40.067 --> 01:18:45.067
fraction, that's a fraction of
course, that toxicity, gets an
organisms

1069
01:18:45.067 --> 01:18:47.000
and people.

1070
01:18:47.000 --> 01:18:52.000
Second part of the question oh,
so, no, actually not the usual
suspects,

1071
01:18:52.000 --> 01:18:57.000
some of them are you usual
suspects reason Ware Shoals,
benzo compound

1072
01:18:57.000 --> 01:19:02.000
I don't know that's a usual
suspect, it's a big player we
see alkylate,

1073
01:19:02.000 --> 01:19:07.000
big players, huge in some cases,
so, if

1074
01:19:07.000 --> 01:19:12.000
you're just looking at the 16
priority pollutants, you are
missing, over

1075
01:19:12.000 --> 01:19:18.000
half the story.

1076
01:19:18.000 --> 01:19:24.000
>> Great, thank you. One more
question, what analytical method
are

1077
01:19:24.000 --> 01:19:28.000
you using, to identify all of
the PAHs? Then, another question
related

1078
01:19:28.000 --> 01:19:32.000
to identification, analytical
methods is, what

1079
01:19:32.000 --> 01:19:37.000
passive sampling devices were
used, why were they chosen?

1080
01:19:37.000 --> 01:19:42.067
>> So, the, most methods, which
are published on,

1081
01:19:42.067 --> 01:19:44.067
so what's SME the person who
asked

1082
01:19:44.067 --> 01:19:48.000
I can study those links actually
also links on our, website you
can

1083
01:19:48.000 --> 01:19:53.000
actually see the analytical
method published on those, most,
of the

1084
01:19:53.000 --> 01:19:59.000
parent PAHs, MS MS, alkylate

1085
01:19:59.000 --> 01:20:05.000
forensic method, which further,
digs down into, many of the
alkylated

1086
01:20:05.000 --> 01:20:11.000
theories, that's also GC MS MS
oxygenated PAH on a single

1087
01:20:11.000 --> 01:20:16.000
quad GC MS, other mixtures are,
also published

1088
01:20:16.000 --> 01:20:21.000
methods, it's, massive what we
call massive 1530 different
chemicals.

1089
01:20:21.000 --> 01:20:25.000
Published also on our website,
you can because it has

1090
01:20:25.000 --> 01:20:30.000
so many chemicals I don't want
to list them, but, those are

1091
01:20:30.000 --> 01:20:33.000
all the methods our website, all
the methods have led to the
publication

1092
01:20:33.000 --> 01:20:38.000
analyst, in which one also on a
website, you can drill down see

1093
01:20:38.000 --> 01:20:42.067
what specific PAHs in each
method, and, more details

1094
01:20:42.067 --> 01:20:46.000
on the method. We use multiple
types of passive sampling

1095
01:20:46.000 --> 01:20:52.000
low density polyethylene used in
the study reason we use that, is

1096
01:20:52.000 --> 01:20:58.000
a captures a really wide range,
seven orders of magnitude

1097
01:20:58.000 --> 01:21:04.000
KO W's KOA's, it allows us to
really look at everything from,

1098
01:21:04.000 --> 01:21:08.000
semi-polar compounds, organic
chemicals, you can see even

1099
01:21:08.000 --> 01:21:15.000
things that have, KO'd up of
like one water-soluble

1100
01:21:15.000 --> 01:21:20.000
coffee, pick up caffeine might
think of is a very water-soluble
compound,

1101
01:21:20.000 --> 01:21:24.000
not, super lipophilic so, we
usually use, because we can use,

1102
01:21:24.000 --> 01:21:29.000
low density polyethylene, we can
actually use, it in both in

1103
01:21:29.000 --> 01:21:33.000
the sediment, in the water, in
the air. There is no confusion
about,

1104
01:21:33.000 --> 01:21:37.000
mixing and matching, different
types of

1105
01:21:37.000 --> 01:21:40.067
passive sampling polymers, to be
able to use the same type of
polymer,

1106
01:21:40.067 --> 01:21:44.067
throughout the whole
environment, and, with the, I
didn't talk about

1107
01:21:44.067 --> 01:21:49.000
it, of course we have silicone,
also passive samplers, both for

1108
01:21:49.000 --> 01:21:54.000
the environment, and for
individual study we will do, so
we would be

1109
01:21:54.000 --> 01:21:57.000
using that for, a little bit
more robustness, people

1110
01:21:57.000 --> 01:22:01.000
who have to wear passive
samplings like silicone
wristbands, it is,

1111
01:22:01.000 --> 01:22:05.000
maintains, flexibility, and,
stretch, a

1112
01:22:05.000 --> 01:22:10.000
bunch of other properties, we
stick with that for individuals,
it show

1113
01:22:10.000 --> 01:22:16.000
that data, everything you saw
today, low density polyethylene.

1114
01:22:16.000 --> 01:22:26.000
Third person a question, I can
remember.

1115
01:22:26.000 --> 01:22:31.000
Make sure we have time for
billet, finish the presentation,
do please

1116
01:22:31.000 --> 01:22:38.000
don't sometime at the end, come
back to a few of those
questions.

1117
01:22:38.000 --> 01:22:43.067
Move on to the Baylor rights SRP
center, first we will hear from,

1118
01:22:43.067 --> 01:22:47.000
Dr. Dr. Bhagavatula Moorthy
Director of neonatology

1119
01:22:47.000 --> 01:22:52.000
research laboratory, Baylor
College of medicine principal,
investigator,

1120
01:22:52.000 --> 01:22:58.000
program director Baylor rights
SRP center, research focuses on,

1121
01:22:58.000 --> 01:23:06.000
the role of P 54 when a one
enzymes, metabolism

1122
01:23:06.000 --> 01:23:10.000
atherogenesis, DNA and
formation, by chemicals.

1123
01:23:10.000 --> 01:23:14.000
This includes research, on the
role of these enzymes, neonatal

1124
01:23:14.000 --> 01:23:23.000
lung injury, newborn mice,
exposed to prenatally, to PAHs.

1125
01:23:23.000 --> 01:23:29.000
Pedro Alvarez, environment and
engineering,

1126
01:23:29.000 --> 01:23:32.000
University, also serves as
founding director,

1127
01:23:32.000 --> 01:23:41.067
of the National Science
Foundation, enabled treatment,

1128
01:23:41.067 --> 01:23:47.000
nanotechnology, mediation, toxic
chemicals, water

1129
01:23:47.000 --> 01:23:52.000
footprint, and biofuels, water
treatment reuse, and about
Kristin's control.

1130
01:23:52.000 --> 01:23:55.000
Dr. Alvarez the leader of the
Baylor rights SRP

1131
01:23:55.000 --> 01:24:00.000
project focused on conversion of
PAHs, contaminant sediment
alumni

1132
01:24:00.000 --> 01:24:04.000
toxicity, enhance soil
fertility.

1133
01:24:04.000 --> 01:24:09.000
Finally, hear from Dr. Sharon
Croisant University of Texas
Medical Branch

1134
01:24:09.000 --> 01:24:15.000
is, Department of preventative
medicine and population health.

1135
01:24:15.000 --> 01:24:19.000
Has more than 20 years of
experience unity engage research
and outreach.

1136
01:24:19.000 --> 01:24:22.000
Serves as a director of the
community engagement core,

1137
01:24:22.000 --> 01:24:26.000
for the Baylor rights SRP center
participated in multiple
products

1138
01:24:26.000 --> 01:24:32.000
asthma exacerbations related to
air pollution,

1139
01:24:32.000 --> 01:24:36.000
humidity stakeholders,
community-based research
important focus of her

1140
01:24:36.000 --> 01:24:40.000
work primarily in response to
emergent and bar mental health
issues, expense

1141
01:24:40.000 --> 01:24:46.934
by Gulf Coast communities,
natural, man-made disasters.
With that, Dr.

1142
01:24:46.934 --> 01:24:52.934
Moorthy I will turn it over to
you.

1143
01:24:52.934 --> 01:24:54.934
Dr.

1144
01:24:54.934 --> 01:24:59.934
I do not hear you right now,
please make sure to unmute your
line, press

1145
01:24:59.934 --> 01:25:15.934
pound six, Dr.

1146
01:25:15.934 --> 01:25:21.934
Moorthy I can hearing opiates,
thank you.

1147
01:25:21.934 --> 01:25:26.934
Thank you very much for the nice
introduction.

1148
01:25:26.934 --> 01:25:32.934
Director of the Baylor College
of medicine, count,

1149
01:25:32.934 --> 01:25:38.934
slides, but able to, let me

1150
01:25:38.934 --> 01:25:45.067
move the sites, to carry if you
make sure he has

1151
01:25:45.067 --> 01:25:51.000
led control, if not, thank you

1152
01:25:51.000 --> 01:25:56.000
very much. So, Dr. Bhagavatula
Moorthy,

1153
01:25:56.000 --> 01:26:01.000
Baylor College of medicine
directly Baylor recently
established

1154
01:26:01.000 --> 01:26:06.000
Superfund research program.
Focus here, is on

1155
01:26:06.000 --> 01:26:12.000
detection early live exposures,
clinical outcomes

1156
01:26:12.000 --> 01:26:15.000
director this program Dr.

1157
01:26:15.000 --> 01:26:21.000
Alvarez and after that Dr.
Sharon

1158
01:26:21.000 --> 01:26:26.000
Croisant. As you know, used in
the fourth largest city

1159
01:26:26.000 --> 01:26:32.000
in the United States. Also,
Harris County one of the largest

1160
01:26:32.000 --> 01:26:33.000
counties in Houston.

1161
01:26:33.000 --> 01:26:39.067
There are about 20 Superfund
sites, Houston area.

1162
01:26:39.067 --> 01:26:43.067
Mended by the federal Superfund
site, those mended for

1163
01:26:43.067 --> 01:26:49.000
the Texas commission on
environmental quality.

1164
01:26:49.000 --> 01:26:54.000
Birthrates in the Houston area,
much higher than the national
average,

1165
01:26:54.000 --> 01:27:00.000
actually, preterm birth rates
11.612%, national

1166
01:27:00.000 --> 01:27:06.000
average 9.6 and, as you can see,
published

1167
01:27:06.000 --> 01:27:12.000
a paper, analysis, and, not only
the preterm birth rate

1168
01:27:12.000 --> 01:27:16.000
you can preterm birth around
Superfund

1169
01:27:16.000 --> 01:27:22.000
sites, makes it a problem much
worse, that it is. Because,
these

1170
01:27:22.000 --> 01:27:27.000
area vulnerable, and, more
preterm birth in this area

1171
01:27:27.000 --> 01:27:33.000
leading to committed
comorbidities. Newborns. So,

1172
01:27:33.000 --> 01:27:37.000
over arcing hypothesis maternal
exposures to polysilicon

1173
01:27:37.000 --> 01:27:43.067
hydrocarbons present in

1174
01:27:43.067 --> 01:27:49.000
Superfund sites increases, the
risk for preterm birth, and,
augments

1175
01:27:49.000 --> 01:27:58.000
the major mobility is,
associated with this such as

1176
01:27:58.000 --> 01:28:07.000
PVD, this is,

1177
01:28:07.000 --> 01:28:13.000
center, director, and, Deputy
Director Pedro Alvarez,

1178
01:28:13.000 --> 01:28:18.000
projects, environmental science
project,

1179
01:28:18.000 --> 01:28:24.000
product one project science
project, environmental projects,
five

1180
01:28:24.000 --> 01:28:30.000
cores, directed different
leaders,

1181
01:28:30.000 --> 01:28:36.000
have the, administered of
engagement core, and,

1182
01:28:36.000 --> 01:28:42.067
have training Corps, we should
support court, dated management

1183
01:28:42.067 --> 01:28:48.000
overall specific gains, we have,

1184
01:28:48.000 --> 01:28:54.000
I'm going to give an overall
view of the overall center,

1185
01:28:54.000 --> 01:28:58.000
strategies for, the age of
measurement, water and soil, aim

1186
01:28:58.000 --> 01:29:03.000
to is, project two and three,
molecule

1187
01:29:03.000 --> 01:29:09.000
mechanisms by which early live
exposure PAH mixtures, can
increase

1188
01:29:09.000 --> 01:29:15.000
preterm birth, then we have,
project four, which is,

1189
01:29:15.000 --> 01:29:18.000
for led by Dr.

1190
01:29:18.000 --> 01:29:24.000
Pedro Alvarez, Superfund sites,

1191
01:29:24.000 --> 01:29:30.000
Houston area, and, then,
specifically

1192
01:29:30.000 --> 01:29:39.067
strategies, public health
burden, PAH not

1193
01:29:39.067 --> 01:29:42.067
engagement core.

1194
01:29:42.067 --> 01:29:46.000
Next goal develop partnerships,
this is mainly for,

1195
01:29:46.000 --> 01:29:52.000
primary syphilis, EPA, ATS DR
also, NAH

1196
01:29:52.000 --> 01:30:01.000
and basket of SRP, all across
United States.

1197
01:30:01.000 --> 01:30:06.000
Training, students disciplinary
matter, we can develop

1198
01:30:06.000 --> 01:30:10.000
next generation scientists
engineers, and clinicians will
make

1199
01:30:10.000 --> 01:30:16.000
fundamental contributions to
environmental health research,
last Corps,

1200
01:30:16.000 --> 01:30:20.000
data analysis Corps, central hub
to manage and integrate, all

1201
01:30:20.000 --> 01:30:26.000
the products and codes we can
increase our goals. This,

1202
01:30:26.000 --> 01:30:32.000
basically shows, projects,
codes,

1203
01:30:32.000 --> 01:30:40.067
so as a set, mentioned, PAH to
focus on, Dr.

1204
01:30:40.067 --> 01:30:44.067
Robyn Tanguay don't have to talk
a lot about PAHs again, focusing

1205
01:30:44.067 --> 01:30:50.000
mainly on, benzoate for

1206
01:30:50.000 --> 01:30:55.000
this project, so, talk about
project two, project

1207
01:30:55.000 --> 01:30:58.000
three. Project to being led by
Dr.

1208
01:30:58.000 --> 01:31:04.000
Melissa Souter, investigate
Superfund sites,

1209
01:31:04.000 --> 01:31:13.000
proximity to epidemics, as you
can see,

1210
01:31:13.000 --> 01:31:17.000
three specific aims one is to
measure, PAH placenta from
existing

1211
01:31:17.000 --> 01:31:23.000
term and preterm we already
have, established by

1212
01:31:23.000 --> 01:31:29.000
Dr. agar. Aim to is to existing
pipeline

1213
01:31:29.000 --> 01:31:34.000
to look at, expression, DNA
placenta,

1214
01:31:34.000 --> 01:31:40.067
integrate the data, PAH level,
also, looking at, applying

1215
01:31:40.067 --> 01:31:46.000
information systems, variable
into --

1216
01:31:46.000 --> 01:31:51.000
PAH exposure, to preterm
distance

1217
01:31:51.000 --> 01:31:57.000
from remediated, active
Superfund sites, this is
basically,

1218
01:31:57.000 --> 01:32:01.000
diagram exactly what,, the 3M's,
also

1219
01:32:01.000 --> 01:32:07.000
how each project, interact with
each of the other projects, such

1220
01:32:07.000 --> 01:32:16.000
projects as well, women were
exposed

1221
01:32:16.000 --> 01:32:25.000
to PAHs from Superfund sites,
interacting with each of the.

1222
01:32:25.000 --> 01:32:31.000
As you can see, this is, recent
data on project

1223
01:32:31.000 --> 01:32:35.000
two, what we did, looked at the
cohort, both preterm,

1224
01:32:35.000 --> 01:32:42.067
term placenta, Superfund sites
and, not Superfund sites,

1225
01:32:42.067 --> 01:32:48.000
extracted, placenta, look at
PAHs as you can see,

1226
01:32:48.000 --> 01:32:54.000
compile preterm, term,
significant increase benzo be

1227
01:32:54.000 --> 01:33:03.000
Florentine, benzoate
significant, compared to term.

1228
01:33:03.000 --> 01:33:08.000
Interesting data, so, inverse
correlation between levels, and
gestational

1229
01:33:08.000 --> 01:33:14.000
age, higher levels, sooner baby
is born, not a good thing.

1230
01:33:14.000 --> 01:33:18.000
This is again to show with our
research,

1231
01:33:18.000 --> 01:33:21.000
health, led by Dr.

1232
01:33:21.000 --> 01:33:26.000
looking at, 81 of the

1233
01:33:26.000 --> 01:33:32.000
metabolite significantly,
between term and preterm,
placenta.

1234
01:33:32.000 --> 01:33:37.000
Technically about project three,
project three led by myself, Dr.

1235
01:33:37.000 --> 01:33:43.067
will intersection.

1236
01:33:43.067 --> 01:33:49.000
Overall goal, is to look at 51
A1.

1237
01:33:49.000 --> 01:33:55.000
potentiation, newborn mice,
PAHs,

1238
01:33:55.000 --> 01:34:01.000
models here, and, basically what
happens in humans,

1239
01:34:01.000 --> 01:34:07.000
so aim is to test the
hypothesis, prenatal exposure,

1240
01:34:07.000 --> 01:34:13.000
by sucking each of these genes,
PAHs, prenatally,

1241
01:34:13.000 --> 01:34:19.000
potential newborn,

1242
01:34:19.000 --> 01:34:25.000
mechanisms, third aim actually
clinical, look at,

1243
01:34:25.000 --> 01:34:37.000
data available, higher exposure
to PAHs, this

1244
01:34:37.000 --> 01:34:43.000
is existing data, already have
data access to the system,

1245
01:34:43.000 --> 01:34:48.934
aim whole, ecstasy, toxicity
PAHs,

1246
01:34:48.934 --> 01:34:57.934
also lead to, toxicity, this is
again,

1247
01:34:57.934 --> 01:35:02.934
interacts with the three
different aims, how,

1248
01:35:02.934 --> 01:35:06.934
project interacts with each of
these project, scientific
projects

1249
01:35:06.934 --> 01:35:12.934
as well as, supported by each of
these energy go,

1250
01:35:12.934 --> 01:35:18.934
going to give a little design,
takedown,

1251
01:35:18.934 --> 01:35:24.934
each of these, these,

1252
01:35:24.934 --> 01:35:33.934
mice, treated PAHs, gestation,

1253
01:35:33.934 --> 01:35:40.000
benzo and the newborns, Ashley,
exposed to

1254
01:35:40.000 --> 01:35:46.000
as you can see, then, newborn
look

1255
01:35:46.000 --> 01:35:52.000
at long, expression PAH,
determine if there is,

1256
01:35:52.000 --> 01:35:56.000
effects of these prenatal PAH
exposures

1257
01:35:56.000 --> 01:35:59.000
of newborns, lung injury.

1258
01:35:59.000 --> 01:36:05.000
Initial clearly show, that,
there is anticipation of lung
injury

1259
01:36:05.000 --> 01:36:12.000
in mice exposed to PAH, lung
injury as you

1260
01:36:12.000 --> 01:36:18.000
can see, sections, when mice
are, exposed,

1261
01:36:18.000 --> 01:36:24.000
lungs are injured, you can see,
the goal of

1262
01:36:24.000 --> 01:36:30.000
the PAH increases, these, clear
response,

1263
01:36:30.000 --> 01:36:36.000
newborns, exposed to these, is

1264
01:36:36.000 --> 01:36:42.067
in effect, most pronounced
effect,

1265
01:36:42.067 --> 01:36:48.000
double hit, exposed both PAHs,
mode lung injury,

1266
01:36:48.000 --> 01:36:54.000
compared to greatest injury,

1267
01:36:54.000 --> 01:36:59.000
this is an interesting
experiment we looked

1268
01:36:59.000 --> 01:37:04.000
at, collaborative we did,
remediated, soils, different

1269
01:37:04.000 --> 01:37:10.000
times using as you can see, what
we did, we

1270
01:37:10.000 --> 01:37:16.000
inspected soil treated mice,
contaminants oil,

1271
01:37:16.000 --> 01:37:22.000
remediated soil, mice what we
did,

1272
01:37:22.000 --> 01:37:27.000
lung, DNA, the DNA as you can
see, quite a bit of DNA

1273
01:37:27.000 --> 01:37:32.000
in this contented soil, then
remediated. Clearly,

1274
01:37:32.000 --> 01:37:36.000
showed a collaboration between
both biomedical project must
science

1275
01:37:36.000 --> 01:37:42.067
project these are very
exciting,. As you

1276
01:37:42.067 --> 01:37:48.000
can see, Corsi, going to, too
much

1277
01:37:48.000 --> 01:37:52.000
into it, mainly to say, promotes
approach training,

1278
01:37:52.000 --> 01:37:57.000
coordinate training, Baler, and
rice

1279
01:37:57.000 --> 01:38:04.000
outstanding graduate program,
coordinate interact with,
engagement code,

1280
01:38:04.000 --> 01:38:12.000
overall goal being, develop
careers, offer opportunities to
these young

1281
01:38:12.000 --> 01:38:18.000
trainees. They are again, he of
people, for entire centers.

1282
01:38:18.000 --> 01:38:24.000
This is again an example of, how
the research supports core,
various

1283
01:38:24.000 --> 01:38:27.000
medical?

1284
01:38:27.000 --> 01:38:33.000
All this data, done by a great,
metabolism

1285
01:38:33.000 --> 01:38:38.000
team, and, team part of their
advance, technology

1286
01:38:38.000 --> 01:38:44.067
led by Dr. Dean Edward, these
kind

1287
01:38:44.067 --> 01:38:48.000
of data actually, what happens,
flows into the data

1288
01:38:48.000 --> 01:38:54.000
management, system, which is
again, led by Dr. Susan Helton,
Dr.

1289
01:38:54.000 --> 01:38:58.000
a great team, there, work very
very

1290
01:38:58.000 --> 01:39:03.000
well, with the research support,
all the data, generated flowing

1291
01:39:03.000 --> 01:39:09.000
to the data management analysis,
implement robust

1292
01:39:09.000 --> 01:39:14.000
analysis plan, also, conduct
missions related matters,
research, and,

1293
01:39:14.000 --> 01:39:19.000
data statistical, a lot of

1294
01:39:19.000 --> 01:39:25.000
publications, have emerged from
this collaboration between

1295
01:39:25.000 --> 01:39:31.000
DMAC and before collaboration
started, this

1296
01:39:31.000 --> 01:39:35.000
is, actually data management
plan, as you can

1297
01:39:35.000 --> 01:39:41.067
see center how, of all the
project data, generated

1298
01:39:41.067 --> 01:39:44.067
actually the impact of it is
much more, then it would be if
we were

1299
01:39:44.067 --> 01:39:49.000
to do all of our products,
individually, this is, center
how,

1300
01:39:49.000 --> 01:39:53.000
Licari mentioned, each of the
project data flows back and
forth, that

1301
01:39:53.000 --> 01:39:59.000
we are waiting, our goal is to,
make sure, meter goals,

1302
01:39:59.000 --> 01:40:05.000
very very collaborative,
integrated manner.

1303
01:40:05.000 --> 01:40:11.000
This is integration of all the
products, like you said,

1304
01:40:11.000 --> 01:40:17.000
Superfund site, exposure project
one, remediation, these

1305
01:40:17.000 --> 01:40:21.000
are two medical projects. As you
can see,

1306
01:40:21.000 --> 01:40:25.000
project to project three. Each
of these, supported by various
code

1307
01:40:25.000 --> 01:40:28.000
publish the goals of the
project.

1308
01:40:28.000 --> 01:40:34.000
Like to take this opportunity
support, Dr.

1309
01:40:34.000 --> 01:40:39.067
for all the feedback and
guidance, program, program
officer,

1310
01:40:39.067 --> 01:40:45.067
for this go to person, thank you
enough for all the feedback

1311
01:40:45.067 --> 01:40:49.000
and help received still
receiving, then, of course also

1312
01:40:49.000 --> 01:40:55.000
Michelle Hickok their help, also
like to

1313
01:40:55.000 --> 01:41:00.000
think, support, available
hospital, like to think each and
everyone

1314
01:41:00.000 --> 01:41:05.000
of these people, trainees also
like to think,

1315
01:41:05.000 --> 01:41:12.000
program administered, for any
question thank you, for your
attention.

1316
01:41:12.000 --> 01:41:17.000
I think you we will go straight
to

1317
01:41:17.000 --> 01:41:19.000
Dr. Alvarez presentation, ask
questions at the

1318
01:41:19.000 --> 01:41:20.000
end.

1319
01:41:20.000 --> 01:41:21.000
>> Thanks.

1320
01:41:21.000 --> 01:41:27.000
>> Thank you very much, we are
very happy to Baylor College of
medicine,

1321
01:41:27.000 --> 01:41:32.000
on this new Superfund center,
want to ask you to please grant

1322
01:41:32.000 --> 01:41:37.000
me access to sled, animated.

1323
01:41:37.000 --> 01:41:40.067
I like to take 10 minutes to
tell you about two products that
are

1324
01:41:40.067 --> 01:41:43.067
being conducted Rice University.

1325
01:41:43.067 --> 01:41:48.000
First when I don't see the
pointer yet, led by, Naomi,
member

1326
01:41:48.000 --> 01:41:51.000
of the national engineering as
well.

1327
01:41:51.000 --> 01:41:56.000
Peter nor Linda,

1328
01:41:56.000 --> 01:42:02.000
participating, focus on
developing of new technologies,

1329
01:42:02.000 --> 01:42:08.000
capabilities. Specifically, this
project one, growing

1330
01:42:08.000 --> 01:42:14.000
for rapid, reliable, detection,
in a nutshell.

1331
01:42:14.000 --> 01:42:19.000
It is combining new compact
methods, for identifying
molecules with

1332
01:42:19.000 --> 01:42:25.000
machine learning approach. This
is to identify PAHs may

1333
01:42:25.000 --> 01:42:29.000
be more bioavailable even more
toxic. Especially when there

1334
01:42:29.000 --> 01:42:35.000
matrices, such as human,
placenta, soil,

1335
01:42:35.000 --> 01:42:41.067
other environmental samples,
and, we are postulating
developing

1336
01:42:41.067 --> 01:42:46.000
rapid sensing technologies,
detection of compounds,

1337
01:42:46.000 --> 01:42:49.000
we result in significant
benefits.

1338
01:42:49.000 --> 01:42:53.000
Better understanding of exposure
to these toxic chemicals,

1339
01:42:53.000 --> 01:42:59.000
identifying when, contaminants
are responsible for human
disease.

1340
01:42:59.000 --> 01:43:03.000
Making it easier, to determine
when practices,

1341
01:43:03.000 --> 01:43:09.000
for example are being effective,
and, on what time scale.

1342
01:43:09.000 --> 01:43:15.000
So currently we know that there
are, already on

1343
01:43:15.000 --> 01:43:19.000
highly advanced technologies,
quantification of PAHs, and,
these

1344
01:43:19.000 --> 01:43:24.000
are mainly, lab-based methods
require, large and expensive

1345
01:43:24.000 --> 01:43:28.000
equipment, and, also be very
time-consuming, if complex
chemical mixtures,

1346
01:43:28.000 --> 01:43:33.000
need to be analyzed, so,
developing portable, or,

1347
01:43:33.000 --> 01:43:38.000
field goal methods, chemical
analysis, highly complex
samples,

1348
01:43:38.000 --> 01:43:42.067
is challenging, but it will be a
major contribution to the field

1349
01:43:42.067 --> 01:43:48.000
of analytical chemistry.

1350
01:43:48.000 --> 01:43:52.000
This project has for specific
games nanoparticles and like to

1351
01:43:52.000 --> 01:43:58.000
collect spectrum admitted by
this compounds, using a method
called,

1352
01:43:58.000 --> 01:44:02.000
surface enhanced spectroscopy
then,

1353
01:44:02.000 --> 01:44:08.000
extend these, also include,
service enhancing absorption
spectra city

1354
01:44:08.000 --> 01:44:13.000
notice to complementary
spectroscopic approaches

1355
01:44:13.000 --> 01:44:16.000
alloy defecation of a known
molecule.

1356
01:44:16.000 --> 01:44:20.000
Third, then, to make this light
based detection

1357
01:44:20.000 --> 01:44:26.000
platform, also, electrical
defect chemical spectra,

1358
01:44:26.000 --> 01:44:32.000
focus of three. And, finally,
use machine learning,

1359
01:44:32.000 --> 01:44:37.000
to identify PAHs PACs complex
mixtures from

1360
01:44:37.000 --> 01:44:39.000
their spectra.

1361
01:44:39.000 --> 01:44:44.000
So our approach, in this product
first compile, acquire,

1362
01:44:44.000 --> 01:44:49.934
spectra of the target molecules,
PAHs we need to identify.

1363
01:44:49.934 --> 01:44:53.934
Then, drain neural network,

1364
01:44:53.934 --> 01:44:58.934
to identify, spectral features
of these molecules, in the
complex

1365
01:44:58.934 --> 01:45:01.934
example. Much like recognition.

1366
01:45:01.934 --> 01:45:06.934
Then, output would be analyzed,
discern

1367
01:45:06.934 --> 01:45:12.934
which PAH other molecules,
present

1368
01:45:12.934 --> 01:45:15.934
in these, complex samples.

1369
01:45:15.934 --> 01:45:20.934
We anticipate, to develop a new,
streamlined and

1370
01:45:20.934 --> 01:45:26.934
method, for detecting
identifying compounds,

1371
01:45:26.934 --> 01:45:31.934
in complex matrices, again,
environmental samples,
eventually,

1372
01:45:31.934 --> 01:45:42.000
this may move, methods,

1373
01:45:42.000 --> 01:45:47.000
buildable approaches, product
number four, which I live,

1374
01:45:47.000 --> 01:45:52.000
together with deals with the

1375
01:45:52.000 --> 01:45:57.000
sediments impacted by PAHs, we
know their numerals approaches,

1376
01:45:57.000 --> 01:46:04.000
other developed, many are
marginally cost-effective or
impractical.

1377
01:46:04.000 --> 01:46:10.000
Bioremediation, I'm a big fan
of, for example, when forming,

1378
01:46:10.000 --> 01:46:14.000
relatively so, often, not only
difficult to accomplish,

1379
01:46:14.000 --> 01:46:19.000
but has potential to generate
more toxic, byproducts.

1380
01:46:19.000 --> 01:46:25.000
And, more aggressive technology,
such as example,

1381
01:46:25.000 --> 01:46:32.000
you can taken rotary kilns, burn
the soil.

1382
01:46:32.000 --> 01:46:37.000
Energy intensive, destroys,
clearly a need for

1383
01:46:37.000 --> 01:46:43.067
more sustainable more
cost-effective approaches,

1384
01:46:43.067 --> 01:46:47.000
involves, composition of organic

1385
01:46:47.000 --> 01:46:54.000
pollutants, elevated
temperatures, atmosphere,

1386
01:46:54.000 --> 01:47:00.000
approach widely used already to
make produce ethylene,

1387
01:47:00.000 --> 01:47:06.000
petroleum, coal, because
pyrolysis involves relatively
low

1388
01:47:06.000 --> 01:47:10.000
temperature, treatment. It
should minimize soil minimize
soil

1389
01:47:10.000 --> 01:47:13.000
composition.

1390
01:47:13.000 --> 01:47:19.000
So our hypothesis, is that,
unlike Burns

1391
01:47:19.000 --> 01:47:24.000
organic matter, destroys soil
this, approach, should

1392
01:47:24.000 --> 01:47:29.000
pollutants into Charlack
material, meets

1393
01:47:29.000 --> 01:47:34.000
cleanup standards, eliminates
toxicity, also, enhances

1394
01:47:34.000 --> 01:47:40.067
soil fertility, changing
reliability into a potential if
you wish.

1395
01:47:40.067 --> 01:47:45.067
And, our objectives three, first
record

1396
01:47:45.067 --> 01:47:51.000
to verify, pyrolysis will
officially renew PAHs,

1397
01:47:51.000 --> 01:47:56.000
eliminate, toxicity. That we
want to characterize

1398
01:47:56.000 --> 01:48:02.000
reaction mechanisms, including,
essential catalytic role some,

1399
01:48:02.000 --> 01:48:08.000
clays may play. Then, this will
of course, tied or inform

1400
01:48:08.000 --> 01:48:12.000
safe, reliable, cost-efficient
design, an application,

1401
01:48:12.000 --> 01:48:18.000
finally, we will develop,
mathematical models,

1402
01:48:18.000 --> 01:48:23.000
that, simulate operating
conditions help us maximize

1403
01:48:23.000 --> 01:48:27.000
the benefits of soil paralysis,
minimizing, energy requirements,

1404
01:48:27.000 --> 01:48:32.000
and associated cost, and,
preliminary results, very in
origin,

1405
01:48:32.000 --> 01:48:38.000
relatively mild conditions,
using pyrolysis do enhance

1406
01:48:38.000 --> 01:48:42.067
soil fertility compared to
incinerated,

1407
01:48:42.067 --> 01:48:48.000
untreated soil. As visualized by
plan progrowth, using letters.
Well

1408
01:48:48.000 --> 01:48:54.000
done, high sensitivity to
hydrocarbon toxicity. As pointed
out, already

1409
01:48:54.000 --> 01:48:59.000
begun to collaborate with,
Baylor College of medicine, more
precisely

1410
01:48:59.000 --> 01:49:06.000
to illustrate, the benefits of,
pyrolytic treatment
detoxification

1411
01:49:06.000 --> 01:49:12.000
here, we are showing
detoxification using

1412
01:49:12.000 --> 01:49:18.000
quantifies, dependents, cellular
enzymes, then,

1413
01:49:18.000 --> 01:49:26.000
essentially showing, larger bars
left to right,

1414
01:49:26.000 --> 01:49:32.000
enzyme activity, detoxification,
the point here more intense,

1415
01:49:32.000 --> 01:49:41.067
treatment is, longer so

1416
01:49:41.067 --> 01:49:47.000
all in all, we expect to
demonstrate, different

1417
01:49:47.000 --> 01:49:53.000
rogatory compliance,
detoxification, and, activity
restoration,

1418
01:49:53.000 --> 01:49:59.000
we can obtain them all,
simultaneously

1419
01:49:59.000 --> 01:50:05.000
intensity, we can control,
temperature, and

1420
01:50:05.000 --> 01:50:10.000
we will, be developing
generalizable principles, to
optimize

1421
01:50:10.000 --> 01:50:15.000
objective system, different
contamination scissors,

1422
01:50:15.000 --> 01:50:19.000
property, thank you for your
attention.

1423
01:50:19.000 --> 01:50:31.000
>> I think I am on, so,

1424
01:50:31.000 --> 01:50:37.000
I am Sharon Croisant

1425
01:50:37.000 --> 01:50:42.067
mission adopt best practices to
work with local leaders,

1426
01:50:42.067 --> 01:50:48.000
humidity center, impacted by the
Superfund sites, facilitate
prevention,

1427
01:50:48.000 --> 01:50:52.000
intervention strategies, that
ultimately result in community

1428
01:50:52.000 --> 01:50:58.000
level reduction exposure to
PAHs, facilitate communication,

1429
01:50:58.000 --> 01:51:01.000
between a monger center members,
community stakeholders we serve,

1430
01:51:01.000 --> 01:51:06.000
to assist our projects for
medications activities,

1431
01:51:06.000 --> 01:51:10.000
projects and of course
supporting our community
programming, to evaluate

1432
01:51:10.000 --> 01:51:16.000
and disseminate our activities
of course.

1433
01:51:16.000 --> 01:51:21.000
So, as Dr. showed, we have 15

1434
01:51:21.000 --> 01:51:26.000
Superfund sites, in Harris
County, 12 in, several in

1435
01:51:26.000 --> 01:51:28.000
the Houston ship Channel area,
alone.

1436
01:51:28.000 --> 01:51:33.000
And, we also have, problems with
our, waterways, as you can see
in

1437
01:51:33.000 --> 01:51:39.067
the lower picture, we are, water
found to be unsafe for

1438
01:51:39.067 --> 01:51:44.067
swimming, and, for fishing
pollution, this is also,

1439
01:51:44.067 --> 01:51:50.000
compounded, by critical
problems, with the city sewer
system.

1440
01:51:50.000 --> 01:51:56.000
Also as Dr.

1441
01:51:56.000 --> 01:52:01.000
pointed out, preterm birth,
going on for quite

1442
01:52:01.000 --> 01:52:05.000
some time, and it's from the
lower map you can see, this is
published

1443
01:52:05.000 --> 01:52:09.000
by Dr. group, you can see,
hotspots, for current of

1444
01:52:09.000 --> 01:52:14.000
preterm birth, several of which
are included in our, attachment

1445
01:52:14.000 --> 01:52:16.000
area.

1446
01:52:16.000 --> 01:52:21.000
Our target communities, include
six neighborhoods, all are

1447
01:52:21.000 --> 01:52:25.000
impacted by Superfund sites,
heavy industrialization, most
also

1448
01:52:25.000 --> 01:52:29.000
struggle with issues, related to
environmental and social
justice,

1449
01:52:29.000 --> 01:52:35.000
as well as poverty and inequity.

1450
01:52:35.000 --> 01:52:42.067
So, facilitate comedic Asians,
do this

1451
01:52:42.067 --> 01:52:48.000
through a number mechanisms,
primarily, we have a robust,
stakeholders

1452
01:52:48.000 --> 01:52:53.000
advisory board, we engage in,
relatively small community
meetings,

1453
01:52:53.000 --> 01:52:59.000
that we term reflecting,
encounter and discovery

1454
01:52:59.000 --> 01:53:02.000
between, science and,
communities, this really
provides

1455
01:53:02.000 --> 01:53:07.000
the opportunity, for our
scientists, our stakeholders,

1456
01:53:07.000 --> 01:53:12.000
and to engage in discussions of
issues, are important to the
communities.

1457
01:53:12.000 --> 01:53:14.000
We want to what we want to do,
for these meetings is
relationship

1458
01:53:14.000 --> 01:53:19.000
Tilden, a Severson lines of
medication, identifying local
needs, priorities.

1459
01:53:19.000 --> 01:53:24.000
Humidity science workshops, a
little bit different, and that,

1460
01:53:24.000 --> 01:53:28.000
these focus based upon European
model of, science shops

1461
01:53:28.000 --> 01:53:33.000
build upon our stakeholder
advisory board discussions,
providing

1462
01:53:33.000 --> 01:53:39.067
both menu, and a time,
discussion of, research
development,

1463
01:53:39.067 --> 01:53:42.067
or, current projects are
ongoing.

1464
01:53:42.067 --> 01:53:50.000
And, processes, how committed he
members have evolved.

1465
01:53:50.000 --> 01:53:54.000
Pepys project related to
projects two and three answering
impact of

1466
01:53:54.000 --> 01:54:00.000
PAHs, pregnancy preterm birth,
our goal is to

1467
01:54:00.000 --> 01:54:06.000
prenatal education, injection,
community clinic

1468
01:54:06.000 --> 01:54:11.000
hope clinic. We have already
received, IRV approval for this
project,

1469
01:54:11.000 --> 01:54:16.000
developed our all of our
materials, but, renewed dietary
guidelines

1470
01:54:16.000 --> 01:54:22.000
published in July, make sure
everything we have, is,

1471
01:54:22.000 --> 01:54:25.000
updated. Once they are vetted,
everything will be translated
for use with

1472
01:54:25.000 --> 01:54:31.000
the clinic's multicultural
population.

1473
01:54:31.000 --> 01:54:37.000
We've also begun to shoot some
photos, videos to supplement

1474
01:54:37.000 --> 01:54:42.000
her education, include, local
fish advisors, and, preferred
selection

1475
01:54:42.000 --> 01:54:46.934
preparation of fish, we've been
very fortunate whatever

1476
01:54:46.934 --> 01:54:50.934
committee partners, volunteered
use of the portable kitchen,
video

1477
01:54:50.934 --> 01:54:55.934
capabilities, so, that we can
videotape, ourselves or students
in

1478
01:54:55.934 --> 01:55:01.934
our committee members apparent,
fish in healthy ways.

1479
01:55:01.934 --> 01:55:03.934
We have a community gardening
project, that

1480
01:55:03.934 --> 01:55:09.934
we had originally, proposed to
be due community card garden

1481
01:55:09.934 --> 01:55:13.934
sit hydroponic gardening at
least the

1482
01:55:13.934 --> 01:55:18.934
time being we just didn't want
to create scenarios, where,
social

1483
01:55:18.934 --> 01:55:20.934
distancing would be difficult.

1484
01:55:20.934 --> 01:55:26.934
This project related to
projects, one and four,

1485
01:55:26.934 --> 01:55:29.934
specifically to avoid
contaminated soil and the
prospect

1486
01:55:29.934 --> 01:55:34.934
eventually transforming our
contaminated areas, into green
spaces,

1487
01:55:34.934 --> 01:55:40.000
so provides opportunity for
education, about the project,
and, so one

1488
01:55:40.000 --> 01:55:44.000
benefit of hydroponic gardening,
enables us to involve our
residency

1489
01:55:44.000 --> 01:55:50.000
when I have, after spots where
they could have, raise bed,

1490
01:55:50.000 --> 01:55:53.000
what we really want to teach
selecting growing, eating fruits
and vegetables

1491
01:55:53.000 --> 01:55:57.000
free from potential
contaminants, this is in
conjunction with two

1492
01:55:57.000 --> 01:56:03.000
of our communities, partners as
well. As you can

1493
01:56:03.000 --> 01:56:09.000
see here, Lance Holbert,

1494
01:56:09.000 --> 01:56:12.000
team members, prototype, as well
the educational program, that
will

1495
01:56:12.000 --> 01:56:16.000
help participants create their
own hydroponic system,

1496
01:56:16.000 --> 01:56:20.000
will provide all the materials,
instruction small groups, and
will

1497
01:56:20.000 --> 01:56:24.000
also videotape the instructional
videos, that will be available

1498
01:56:24.000 --> 01:56:30.000
by Internet.

1499
01:56:30.000 --> 01:56:36.000
Here you see, a map of PCBs
dioxins, created by Houston,

1500
01:56:36.000 --> 01:56:39.067
Galveston area Council.

1501
01:56:39.067 --> 01:56:45.067
Maintain up-to-date, impressive
set of maps,

1502
01:56:45.067 --> 01:56:48.000
that, very few chemicals are
included, so one of the things
that we have

1503
01:56:48.000 --> 01:56:55.000
been doing, collecting data on,
PAH sampling done, local
waterways,

1504
01:56:55.000 --> 01:57:00.000
also sampling that minute
involved, PAHs perhaps we could
get samples

1505
01:57:00.000 --> 01:57:05.000
from, those groups, so, we've
created two infographics based

1506
01:57:05.000 --> 01:57:09.000
on the data we've compiled, of
course we continue to add to
that data,

1507
01:57:09.000 --> 01:57:13.000
we would like to obtain her own
samples as well.

1508
01:57:13.000 --> 01:57:17.000
These are couple of infographics
we've developed, happy to share,

1509
01:57:17.000 --> 01:57:23.000
if anyone is interested, one
shows results of the mapping,
analysis,

1510
01:57:23.000 --> 01:57:28.000
second contains quite a bit more
information

1511
01:57:28.000 --> 01:57:36.000
next steps, to further develop
the implement six

1512
01:57:36.000 --> 01:57:40.067
schedules, for November and
December, different locations,
throughout

1513
01:57:40.067 --> 01:57:46.000
the area, rather than, proposed
one larger meeting,

1514
01:57:46.000 --> 01:57:49.000
don't want to set of situation
social distancing

1515
01:57:49.000 --> 01:57:53.000
would be a problem, each of
these meetings, will be
facilitated, local

1516
01:57:53.000 --> 01:57:56.000
community partner.

1517
01:57:56.000 --> 01:57:59.000
We are also preparing for our
first hydroponic workshop, just
a couple

1518
01:57:59.000 --> 01:58:02.000
of weeks. And then, we are,
working with the new faculty
member for

1519
01:58:02.000 --> 01:58:06.000
the develop programs geared
towards local fishermen.

1520
01:58:06.000 --> 01:58:12.000
Including, sampling of seafood,
and of water. That was all I
had.

1521
01:58:12.000 --> 01:58:17.000
>> Great, thank you so much, Dr.
Morrissey, Dr. Alvarez,

1522
01:58:17.000 --> 01:58:21.000
Dr. Croisant we are the end of
our time I will

1523
01:58:21.000 --> 01:58:25.000
remind you fidget spinner
question Samiti one to the Q&A
part we will

1524
01:58:25.000 --> 01:58:30.000
absolutely get those to the
presenters, so

1525
01:58:30.000 --> 01:58:32.000
that they can, if they, they are
able to they can follow up with

1526
01:58:32.000 --> 01:58:36.000
you, separately. So at this
point, I would like to say thank
you so

1527
01:58:36.000 --> 01:58:41.067
much, to all three of those
wonderful presentations from the
three centers,

1528
01:58:41.067 --> 01:58:46.000
I would also like to, encourage
everyone, if

1529
01:58:46.000 --> 01:58:52.000
you are still with us, please
join us, on, November 9th,

1530
01:58:52.000 --> 01:58:56.000
and November 19th, for the
remaining two sessions, in this
series. That's

1531
01:58:56.000 --> 01:58:59.000
one hear from SRP Center,
Northeastern University,

1532
01:58:59.000 --> 01:59:04.000
University of Alabama,
Birmingham, if you

1533
01:59:04.000 --> 01:59:09.000
like to join his wet webinars,
register now, register filling
up fast. With

1534
01:59:09.000 --> 01:59:16.000
that, time to conclude today's
webinar, if

1535
01:59:16.000 --> 01:59:19.000
you submitted a question, it is
to receptors, did not time to
get

1536
01:59:19.000 --> 01:59:21.000
to it. Thank you again, all of
our presenters, those excellent
presentations,

1537
01:59:21.000 --> 01:59:27.000
all three centers. With that,
thank you, everyone for joining
us today,

1538
01:59:27.000 --> 01:59:32.000
the sense today's webinar.