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• March 16, 2004
• May 18, 2004

One of the goals of Superfund Basic Research Program is the development of methods and technologies to detect, assess and evaluate the effects of toxic substances on human health. This is the second of two seminars on Biosensors for Environmental Monitoring sponsored by the NIEHS Superfund Basic Research Program and the EPA Technology Innovation Program. Dr. Patrick Larkin of EcoArray, Inc. will describe their work to develop gene chips, as well as related products, for several key wildlife models of interest to the Environmental Protection Agency (EPA) and other governmental agencies as sentinel species for research and risk assessment. He will describe experiments using gene chips in fathead minnows, sheepshead minnows, and largemouth bass to illustrate the use of these powerful tools. In addition, Dr. Elwood Linney of Duke University will present his work on the zebrafish model and place it within the context of mammalian models that are used to investigate the effects of environmental toxicants. Considerable technology has developed around this vertebrate model and it is best viewed as a model that can complement studies with rodent models. Some advantages of this model include its embryonic development outside of the mother, the visibility of its organs as they develop, and the relative small size of the embryos as its develop so that a variety of microscopic techniques can be used to visualize events.

• Patrick Larkin, Ph.D, EcoArray, Inc. (pmlarkin@ecoarray.com)
• Elwood Linney, Ph.D., Duke University (elwood.linney@duke.edu)

• Larry Whitson, National Institutes of Health, National Institute of Environmental Health Sciences (whitson@niehs.nih.gov)

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