The NIEHS Superfund Research Program (SRP) presents the third session in the Risk e-Learning series SRP Water Innovation - An Integrated Approach to Sustainable Solutions. Session III – Water Detection Technologies will feature SRP-funded projects that are developing innovative technologies for the monitoring of hazardous substances in water. The presentations will highlight potential non-targeted testing, passive sampling, and bioanalytical approaches to detect a wide variety of contaminants in water, with applicability to drinking water.
Roger Giese, Ph.D., from the Puerto Rico Testsite for Exploring Environmental Contaminants (PROTECT) SRP Center at Northeastern University, will present nontargeted tea bag extraction/mass spectrometry methodology for large urine and water samples, in regard to the problem of preterm birth. This will include analysis of sulfated exposome metabolites in urine and of pollutants in ground water samples from Puerto Rico. The tea bag technique may also become of interest for purification of drinking water by the consumer.
Damian Shea, Ph.D., a professor at North Carolina State University and investigator with the University of North Carolina at Chapel Hill SRP Center, will discuss combining target and non-target analysis with passive sampling devices to measure the external organic chemical exposome in water. As, they have developed a non-selective passive sampling device (nsPSD) that accumulates both polar and non-polar organic chemicals (log Kow range 0.2-8.0) from water and combined this with analysis using both target chemical and non-target chemical methods using LCMS and GCMS. Results from surface waters at Superfund sites and elsewhere will be presented and used to illustrate some advantages and limitations of these new methodologies for assessing risk associated with chemicals in drinking water and fish and shellfish.
Michael Denison, Ph.D., Thomas Young, Ph.D., and Candace Bever, Ph.D., from the University of California, Davis Superfund Research Center will discuss their work on developing bioanalytical tools for the detection of hazardous chemicals. They will introduce how cell-based assays provide an understanding of how hazardous chemicals interact with human receptors, while antibody-based assays are quantitative analytical tools. Examples from water sources in the Sierra Nevada Mountains and from the LA Basin in Southern California will be presented. They will further discuss how cell-based bioassays can be useful in screening large numbers of samples and then directly informing the use of high-resolution mass spectrometry to identify known and unknown hazardous chemicals.