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• March 28, 2012

The second session "Early Life Exposures - Long-term Health Consequences: Session 2, Metals and Metal Mixtures" features SRP grantees Dr. Robert Wright (Harvard University) and Dr. Rebecca Fry (UNC-CH) and their work with early exposure to metals and the resulting developmental effects. To better understand the neurodevelopmental consequences of exposure to mixtures of lead, manganese, and arsenic, Dr. Wright is conducting three cohort studies of metals and neurodevelopment among populations of children in Bangladesh, Mexico and Oklahoma. The combined efforts of these studies investigate the effects of mixed metal exposures on child development, comparing different developmental windows of exposure from prenatal life to age two.

Prenatal exposure to cadmium has been associated with poor birth outcomes including low birth weight. Dr. Fry's research aims to obtain a better understanding of the underlying biological mechanisms involved in this association. This study employs in vitro and in vivo approaches to investigate gene-environment interactions that influence cadmium-induced signaling of inflammatory response genes.

Robert Wright (rowright@hsph.harvard.edu)
Harvard University- Grant P42ES16454
Project: "Epidemiology of Developmental Windows, Metal Mixtures and Neurodevelopment"
The neurodevelopmental consequences of exposure to mixtures of lead, manganese, and arsenic are poorly understood. Dr. Wright is conducting three cohort studies of metals and neurodevelopment, among populations of children in Bangladesh, Mexico and Oklahoma. The combined efforts of these studies investigate the effects of mixed metal exposures on child development, comparing different developmental windows of exposure from prenatal life to age two.

Rebecca Fry (rfry@email.unc.edu)
Harvard University- Grant P42ES16454
Project: "Elucidating Mechanisms of Metal-Induced Toxicity and Disease"
This project aims to obtain better understanding of the underlying biological mechanisms involved in the association between low birth weight and prenatal metal exposure. Through in vitro and in vivo approaches, Dr. Fry investigates gene-environment interactions that influence metal-induced signaling of inflammatory response genes to determine the association of pathway modulation with birth weight and fetal growth.

• Robert Wright, Associate Professor of Pediatrics & Environmental Health, Director, Superfund Research Program, Harvard Medical School and School of Public Health (rowright@hsph.harvard.edu)
• Rebecca Fry, Assistant Professor, Environmental Sciences & Engineering, University of North Carolina Gillings School of Global Public Health (rfry@email.unc.edu)

• Bill Hagel, U.S. EPA, Region 3 (hagel.bill@epa.gov)

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