To test oxidation of an AFFF sample in laboratory soil-water microcosm systems, oxidation was undertaken by low-pH and high-pH catalyzed hydrogen peroxide and alkaline-activated persulfate at varying application doses, resulting in the formation of products with a lower molecular weight and a reduction in the length of the fluorinated tail when compared to the composition of the stock AFFF solution used for testing. These shorter-chained oxidation products seemed to have different sorption characteristics in the soil-water microcosm. Oxidation provided the expected variable levels of treatment based on oxidant used and extent of oxidation.