U.S. EPA Contaminated Site Cleanup Information (CLU-IN)

U.S. Environmental Protection Agency
U.S. EPA Technology Innovation and Field Services Division

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CLU-IN's ongoing series of Internet Seminars are free, web-based slide presentations with a companion audio portion. We provide two options for accessing the audio portion of the seminar: by phone line or streaming audio simulcast. More information and registration for all Internet Seminars is available by selecting the individual seminar below. Not able to make one of our live offerings? You may also view archived seminars.

November 2017
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Download seminar information in iCalendar formatAdverse Outcome Pathways: Session I...


Adverse Outcome Pathways: Session II - Assembling and Assessing AOP Information

The NIEHS Superfund Research Program (SRP) is hosting a seminar series focused on adverse outcome pathways (AOPs), which are structured ways to represent biological events leading to adverse health effects. In the second session, presenters will discuss the development of AOPs and how they may be used to support hazard and risk assessment.

Carole Yauk, Ph.D., will briefly review common AOP development principles, including identifying key events, and assembling and weighing the evidence to support key event relationships and the overall AOP. A case study will then walk through development of one AOP using the AOP wiki. Using alkylation of DNA as the molecular initiating event, subsequent key events that are measurable and essential will be identified. Key event relationships will be identified and evaluated by assessing the dose, incidence and temporal relationships among the events. The essentiality of each event to the adverse outcome, heritable mutations, will be assessed and the empirical evidence supporting the AOP, and any uncertainties, will be evaluated.

Ed Perkins, Ph.D., will discuss efforts to merge the AOP's simple framework for linking effects to a regulated outcome with more biological pathways and measurements such as omics that try to capture the complexity of biology in order to support hazard and risk assessment. Examples will be given on how 'omics and other data can be used in the context of AOPs to assess chemical mixture impacts and how in vitro or in vivo data can be used to determine the likelihood of an AO occurring (e.g. Bayesian AOP networks and mechanistic qAOPs).

The AOP framework provides a logical mechanism based structure for formalizing and visualizing the molecular intersection between chemical and nonchemical stressors. However, the impact and relevance of biomedical research public health protection from chemical and nonchemical exposures depends both on the understanding of mechanisms embedded in the AOP framework, and how exposures themselves affect those mechanisms and the likelihood of adverse outcomes.

Justin Teeguarden, Ph.D., will introduce similar frameworks for organizing exposure information (like the aggregate exposure pathway (AEP)) and discuss how they can provide critical information about the magnitude of the stress and key information about how environmental concentrations can be related to human exposures. He will also discuss how exposures in studies conducted in vitro or an animal models can be related to human exposures.

This webinar is also in support of an upcoming NIEHS/NHLBI Workshop, Understanding the Combined Effects of Environmental Chemical and Non-Chemical Stressors: Atherosclerosis as a Model, which will take place at NIEHS in Research Triangle Park, North Carolina, April 3 - 4, 2018. The goal of this workshop is to identify key biological mechanisms and pathways of the combined effects of chemical and non-chemical stressors associated with atherosclerosis. This workshop will use the AOP framework to assist in the discussion of the pathways considered by workshop participants.
Interstate Technology Regulatory Council
Seminars Sponsored by the Interstate Technology and Regulatory Council

Remedy Selection for Contaminated Sediments

Interstate Technology Regulatory Council The sediments underlying many of our nationís major waterways are contaminated with toxic pollutants from past industrial activities. Cleaning up contaminated sediments is expensive and technically-challenging. Sediment sites are unique, complex, and require a multidisciplinary approach and often project managers lack sediments experience. ITRC developed the technical and regulatory guidance, Remedy Selection for Contaminated Sediments (CS-2, 2014), to assist decision-makers in identifying which contaminated sediment management technology is most favorable based on an evaluation of site specific physical, sediment, contaminant, and land and waterway use characteristics. The document provides a remedial selection framework to help identify favorable technologies, and identifies additional factors (feasibility, cost, stakeholder concerns, and others) that need to be considered as part of the remedy selection process. This ITRC training course supports participants with applying the technical and regulatory guidance as a tool to overcome the remedial challenges posed by contaminated sediment sites. Participants learn how to:
  • Identify site-specific characteristics and data needed for site decision making
  • Evaluate potential technologies based on site information
  • Select the most favorable contaminant management technology for their site
For reference during the training class, participants should have a copy of Figure 2-1, Framework for Sediment Remedy Evaluation. It is available as a 1-page PDF at http://www.cluin.org/conf/itrc/ContSedRem/ITRC-SedimentRemedyEvaluation.pdf.

Participants should also be familiar with the ITRC technology and regulatory guidance for Incorporating Bioavailability Considerations into the Evaluation of Contaminated Sediment Sites Website (CS-1, 2011) and associated Internet-based training that assists state regulators and practitioners with understanding and incorporating fundamental concepts of bioavailability in contaminated sediment management practices.

Groundwater Statistics for Environmental Project Managers

Interstate Technology Regulatory Council Statistical techniques may be used throughout the process of cleaning up contaminated groundwater. It is challenging for practitioners, who are not experts in statistics, to interpret, and use statistical techniques. ITRC developed the Technical and Regulatory Web-based Guidance on Groundwater Statistics and Monitoring Compliance (GSMC-1, 2013, http://www.itrcweb.org/gsmc-1/) and this associated training specifically for environmental project managers who review or use statistical calculations for reports, who make recommendations or decisions based on statistics, or who need to demonstrate compliance for groundwater projects. The training class will encourage and support project managers and others who are not statisticians to:

ITRC's Technical and Regulatory Web-based Guidance on Groundwater Statistics and Monitoring Compliance (GSMC-1, 2013) and this associated training bring clarity to the planning, implementation, and communication of groundwater statistical methods and should lead to greater confidence and transparency in the use of groundwater statistics for site management.

Geospatial Analysis for Optimization at Environmental Sites

Interstate Technology Regulatory Council Optimization activities can improve performance, increase monitoring efficiency, and support contaminated site decisions. Project managers can use geospatial analysis for evaluation of optimization opportunities. Unlike traditional statistical analysis, geospatial methods incorporate the spatial and temporal dependence between nearby data points, which is an important feature of almost all data collected as part of an environmental investigation. The results of geospatial analyses add additional lines of evidence to decision making in optimization opportunities in environmental sites across all project life cycle stages (release detection, site characterization, remediation, monitoring and closure) in soil, groundwater or sediment remediation projects for different sizes and types of sites.

The purpose of ITRC's Geospatial Analysis for Optimization at Environmental Sites (GRO-1) guidance document and this associated training is to explain, educate, and train state regulators and other practitioners in understanding and using geospatial analyses to evaluate optimization opportunities at environmental sites. With the ITRC GRO-1 web-based guidance document and this associated training class, project managers will be able to:
  • Evaluate available data and site needs to determine if geospatial analyses are appropriate for a given site
  • For a project and specific lifecycle stage, identify optimization questions where geospatial methods can contribution to better decision making
  • For a project and optimization question(s), select appropriate geospatial method(s) and software using the geospatial analysis work flow, tables and flow charts in the guidance document
  • With geospatial analyses results (note: some geospatial analyses may be performed by the project manager, but many geospatial analyses will be performed by technical experts), explain what the results mean and appropriately apply in decision making
  • Use the project managerís tool box, interactive flow charts for choosing geospatial methods and review checklist to use geospatial analyses confidently in decision making
The Training Exchange (Trainex)

The Training Exchange website (Trainex) is designed to provide a wide range of training information to EPA, other federal agency, state, tribal, and local staff involved in hazardous waste management and remediation. Trainex focuses on free training directed to federal and state staff. This site includes training schedules for deliveries of many courses, both classroom and Internet-based.

EPA works in partnership with organizations, such as the Interstate Technology Regulatory Council (ITRC), and other agencies, such as the Agency for Toxic Substances and Disease Registry (ATSDR), to offer training relevant to hazardous waste remediation, site characterization, risk assessment, emergency response, site/incident management, counter-terrorism, and the community's role in site management and cleanup.

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