The cleaning of soils highly contaminated with 2,4-dinitrotoluene (2,4-DNT) and 2,6-dinitrotoluene (2,6-DNT) was examined in a pilot-scale bioslurry system. The treatment scheme involved a soil-washing process followed by two sequential aerobic slurry reactors augmented with bacteria capable of mineralizing the explosive compounds. Soil washing was used to minimize operational problems associated with large particulates in slurry reactors. Eimco slurry reactors were operated in a draw-and-fill mode for three months and monitored for the biodegradation of 2,4-DNT and 2,6-DNT, nitrite production, NaOH consumption, and oxygen uptake rate. The process was very effective for the removal of sands and the recovery of soil fines containing 2,4-DNT and 2,6-DNT, though the reactors required real-time monitoring to avoid long lag periods upon refeeding. Results showed a significant discrepancy between the measured DNT concentrations and calculated DNT concentrations in the slurry reactors due to solids profiles in the slurry reactors and the presence of floating crystal of DNTs.