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SOIL DIOXIN RELATIVE BIOAVAILABILITY ASSAY EVALUATION FRAMEWORK
U.S. Environmental Protection Agency, OSWER 9200.2-136, 16 pp, 2015
Until standard procedures for estimating the relative bioavailability (RBA) of PCDD/F in soil are established, there is a need for a consistent approach to evaluate the strengths and weaknesses of assays designs proposed or implemented to support risk assessments. This report offers a framework for making such evaluations. Specific design parameters that should be subject to evaluation are identified and relevant scientific literature is cited where more in-depth discussion can be found. Whenever possible, minimal requirements for study designs are proposed. This report also identifies issues that have yet to be resolved regarding how RBA assays should be designed and which could be objectives of further research to develop RBA assays for soil PCDD/F and applications to risk assessment. http://semspub.epa.gov/src/document/HQ/175334
Until standard procedures for estimating the relative bioavailability (RBA) of PCDD/F in soil are established, there is a need for a consistent approach to evaluate the strengths and weaknesses of assays designs proposed or implemented to support risk assessments. This report offers a framework for making such evaluations. Specific design parameters that should be subject to evaluation are identified and relevant scientific literature is cited where more in-depth discussion can be found. Whenever possible, minimal requirements for study designs are proposed. This report also identifies issues that have yet to be resolved regarding how RBA assays should be designed and which could be objectives of further research to develop RBA assays for soil PCDD/F and applications to risk assessment. http://semspub.epa.gov/src/document/HQ/175334
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