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MULTI-SITE STUDY OF THE HEALTH IMPLICATIONS OF EXPOSURE TO PFAS-CONTAMINATED DRINKING WATER
Department of Health and Human Services, Agency for Toxic Substances and Disease Registry (ATSDR), Funding Opportunity RFA-TS-19-002, 2019

ATSDR is soliciting research to commence a multi-site study on the human health effects of exposures to drinking water contaminated with per- and polyfluoroalkyl substances (PFASs). Proposed study sites must include communities using PFAS-contaminated private residential wells or public water systems. Exposure assessment will be based on measured PFAS serum levels as well as estimated serum levels derived from pharmacokinetic modeling of reconstructed PFAS drinking water concentrations over time. Grant awardees will conduct historical reconstruction/water modeling to determine PFAS concentration and evaluate effect biomarkers such as lipids and tests of immune and thyroid function derived from pharmacokinetic modeling of reconstructed PFAS drinking water concentrations over time. ATSDR intends this research to be a 2-part program consisting of (1) a mandatory core research protocol to allow ATSDR to aggregate the core data and compare lab and statistical analyses across sites, and (2) options to propose additional investigator-initiated research questions and hypotheses related to the overall goals of this funding opportunity. The closing date for applications is May 30, 2019. Up to 6 awards from estimated total program funding of $32.5M is anticipated: Award Ceiling $3M, Award Floor $500,000. https://www.grants.gov/web/grants/view-opportunity.html?oppId=314434



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