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INTEGRATING TOOLS FOR NON-TARGETED ANALYSIS RESEARCH AND CHEMICAL SAFETY EVALUATIONS AT THE U.S. EPA
Sobus, J.R., J.F. Wambaugh, K.K. Isaacs, A.J. Williams, A.D. McEachran, A.M. Richard, et al.
Journal of Exposure Science & Environmental Epidemiology 28(5):411-426(2018)

New tools have been developed to enable rapid assessment of potentially harmful chemical exposures and their attendant biological responses. One group of tools—"non-targeted analysis" (NTA) methods—allows the rapid characterization of thousands of never-before-studied compounds in a wide variety of environmental, residential, and biological media. This article discusses current applications of NTA methods, challenges to their effective use in chemical screening studies, and ways in which shared resources (e.g., chemical standards, databases, model predictions, and media measurements) can advance their use in risk-based chemical prioritization. Resources and projects within EPA's Office of Research and Development (ORD) provide and receive benefits relevant to NTA research endeavors, including EPA's Non-Targeted Analysis Collaborative Trial and a research framework that shows how NTA methods will bridge chemical prioritization efforts within ORD. The framework exists as a guide for institutions seeking to understand the complexity of chemical exposures and the impact of the exposures on living systems. https://www.nature.com/articles/s41370-017-0012-y



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