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Zhang, S., Master's Thesis, University of California Los Angeles, 109 pp, 2017

This research aimed to measure and model the effects of chlorinated solvents on 1,4-dioxane metabolic biodegradation, elucidate the mechanisms of the inhibition, and test the effects of mixtures of co-contaminants in samples collected from actual 1,4-dioxane contaminated sites. Individual solvents inhibited biodegradation of 1,4-dioxane in the following order: 1,1-DCE >cDCE >TCE>TCA. Genes for catalytic enzymes, dioxane monooxygenase (dxmB) and alcohol dehydrogenase (aldH) were reduced in the presence of chlorinated solvents. Results are useful to understand the fundamentals of enzymatic processes that catalyze biological degradation of hazardous compounds and provide quantitative data for the development of in situ bioremediation approaches for contaminant mixtures. https://escholarship.org/content/qt1526m401/qt1526m401.pdf?t=oq1src

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